Intermediates involved in the two electron reduction of NO to N2O by a functional synthetic model of heme containing bacterial NO reductase.

Intermediates involved in the two electron reduction of NO to N2O by a functional synthetic model of heme containing bacterial NO reductase.
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DOI:
10.1021/ja807700n
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发表时间:
2008-12-10
影响因子:
15
通讯作者:
Solomon EI
Solomon EI
中科院分区:
化学1区
文献类型:
--
作者:
Collman JP;Dey A;Yang Y;Decréau RA;Ohta T;Solomon EI

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功能性双铁血红素/非血红素模型复合物在低温下的反应导致形成远端非血红素亚硝酰基,随后形成反式血红素非血红素​​双亚硝酰基中间体。该中间体的 EPR 和拉曼数据表明两个亚硝酰基中心很接近。该复合物释放出 N2O,并为 NOR 酶提出的反式机制提供支持。
Reaction of a functional biferrous heme/nonheme model complex at low temperature leads to the formation of a distal nonheme nitrosyl followed by a trans heme nonheme bis-nitrosyl intermediate. The EPR and Raman data on this intermediate indicate that the two nitrosyl centers are close. This complex gives off N2O and provides support for the trans mechanism proposed for NOR enzymes.
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