Comparing apples and oranges: Why infant bone collagen may not reflect dietary intake in the same way as dentine collagen.
Comparing apples and oranges: Why infant bone collagen may not reflect dietary intake in the same way as dentine collagen.
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DOI：
10.1002/ajpa.23682
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发表时间：
2018-11
影响因子：
2.8
通讯作者：
Montgomery J
中科院分区：
文献类型：
--
作者：
Beaumont J;Atkins EC;Buckberry J;Haydock H;Horne P;Howcroft R;Mackenzie K;Montgomery J
增量牙本质分析的最新发展允许提高生命最初 1,000 天期间形成的组织的时间分辨率，这使人们对使用婴儿骨胶原碳 (δ13C) 和氮 (δ15N) 同位素比率数据进行的断奶研究的准确性产生了怀疑。在这里，我们将英国 Raunds Furnells 保存完好的盎格鲁撒克逊遗址的已发表骨骼数据与同一个体的共形成牙本质进行比较，并研究这些数据与青少年身高的关系。牙本质中记录的高分辨率同位素数据使我们能够研究这一生命关键时期的饮食与青少年身高的关系。我们将增量牙本质胶原蛋白 δ13C 和 δ15N 数据与已发表的来自 Anglo Saxon Raunds Furnells 的 18 名青少年和 5 名成年女性的骨胶原数据以及青少年骨骼和牙齿年龄的新数据进行了比较。该方法的改进是通过对牙尖下或切牙下牙本质的前 0.5 毫米进行采样，从而可以对子宫内形成的牙本质进行同位素测量。牙本质和骨骼的 δ13C 谱与 δ15N 相似且更稳健，可用于估计开始断奶食物的年龄。我们的结果表明，牙本质的 δ15N 值可用于评估怀孕期间母体/子宫内饮食和生理机能，并且婴儿牙本质特征可能反映饮食加上生理应激因素。特别是，骨胶原无法记录与共形成牙本质相同的 δ15N 范围，特别是在生长发育迟缓的情况下，这表明婴儿骨胶原对于断奶研究来说并不可靠。
Recent developments in incremental dentine analysis allowing increased temporal resolution for tissues formed during the first 1,000 days of life have cast doubt on the veracity of weaning studies using bone collagen carbon (δ13C) and nitrogen (δ15N) isotope ratio data from infants. Here, we compare published bone data from the well‐preserved Anglo‐Saxon site of Raunds Furnells, England, with co‐forming dentine from the same individuals, and investigate the relationship of these with juvenile stature. The high‐resolution isotope data recorded in dentine allow us to investigate the relationship of diet with juvenile stature during this critical period of life. We compare incremental dentine collagen δ13C and δ15N data to published bone collagen data for 18 juveniles and 5 female adults from Anglo Saxon Raunds Furnells alongside new data for juvenile skeletal and dental age. An improvement in the method by sampling the first 0.5 mm of the sub‐cuspal or sub‐incisal dentine allows the isotopic measurement of dentine formed in utero. δ13C profiles for both dentine and bone are similar and more robust than δ15N for estimating the age at which weaning foods are introduced. Our results suggest δ15N values from dentine can be used to evaluate the maternal/in utero diet and physiology during pregnancy, and that infant dentine profiles may reflect diet PLUS an element of physiological stress. In particular, bone collagen fails to record the same range of δ15N as co‐forming dentine, especially where growth is stunted, suggesting that infant bone collagen is unreliable for weaning studies.
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影响因子：
3.6
作者：
de Luca, Arnaud;Boisseau, Nathalie;Hankard, Regis
通讯作者：
Hankard, Regis
影响因子：
3.7
作者：
Beaumont J;Montgomery J
通讯作者：
Montgomery J
影响因子：
2.8
作者：
Beaumont, Julia;Montgomery, Janet;Jay, Mandy
通讯作者：
Jay, Mandy
影响因子：
1.6
作者：
Beaumont, J.;Gledhill, A.;Montgomery, J.
通讯作者：
Montgomery, J.
影响因子：
2
作者：
Fuller, BT;Fuller, JL;Hedges, REM
通讯作者：
Hedges, REM