Zinc in Wound Healing Modulation.
Zinc in Wound Healing Modulation.
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作者：
Lin PH;Sermersheim M;Li H;Lee PHU;Steinberg SM;Ma J
伤口护理是一项主要的医疗保健支出。烧伤、手术和创伤伤口、糖尿病下肢溃疡和皮肤伤口的治疗是一项重大的医疗挑战，目前的治疗主要集中在支持性护理措施上。成功的伤口修复需要一系列紧密协调的步骤，包括凝血、炎症、血管生成、新组织形成和细胞外基质重塑。锌是人体必需的微量元素，在人体生理中起着重要的作用。锌是细胞膜修复、细胞增殖、生长和免疫系统功能所需的许多金属酶的辅因子。锌缺乏的病理效应包括皮肤病变、生长迟缓、免疫功能受损和伤口愈合不良。在这里，我们讨论锌在调节伤口愈合过程中的细胞和分子机制的调查。从这一研究机构获得的知识将有助于将这些发现转化为未来的伤口愈合临床管理。
Wound care is a major healthcare expenditure. Treatment of burns, surgical and trauma wounds, diabetic lower limb ulcers and skin wounds is a major medical challenge with current therapies largely focused on supportive care measures. Successful wound repair requires a series of tightly coordinated steps including coagulation, inflammation, angiogenesis, new tissue formation and extracellular matrix remodelling. Zinc is an essential trace element (micronutrient) which plays important roles in human physiology. Zinc is a cofactor for many metalloenzymes required for cell membrane repair, cell proliferation, growth and immune system function. The pathological effects of zinc deficiency include the occurrence of skin lesions, growth retardation, impaired immune function and compromised would healing. Here, we discuss investigations on the cellular and molecular mechanisms of zinc in modulating the wound healing process. Knowledge gained from this body of research will help to translate these findings into future clinical management of wound healing.
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影响因子：
--
作者：
Cho JG;Park S;Lim CH;Kim HS;Song SY;Roh TY;Sung JH;Suh W;Ham SJ;Lim KH;Park SG
通讯作者：
Park SG
影响因子：
4.9
作者：
Boo, Stellar;Dagnino, Lina
通讯作者：
Dagnino, Lina
影响因子：
7.1
作者：
Besecker, Beth Y.;Exline, Matthew C.;Knoell, Daren L.
通讯作者：
Knoell, Daren L.
DOI：
10.1111/j.1532-5415.2009.02351.x
发表时间：
2009-08-01
影响因子：
6.3
作者：
Cereda, Emanuele;Gini, Anna;Vanotti, Alfredo
通讯作者：
Vanotti, Alfredo
影响因子：
30.3
作者：
Botella H;Peyron P;Levillain F;Poincloux R;Poquet Y;Brandli I;Wang C;Tailleux L;Tilleul S;Charrière GM;Waddell SJ;Foti M;Lugo-Villarino G;Gao Q;Maridonneau-Parini I;Butcher PD;Castagnoli PR;Gicquel B;de Chastellier C;Neyrolles O
通讯作者：
Neyrolles O