Progression along the bipolar spectrum: a longitudinal study of predictors of conversion from bipolar spectrum conditions to bipolar I and II disorders.
Progression along the bipolar spectrum: a longitudinal study of predictors of conversion from bipolar spectrum conditions to bipolar I and II disorders.
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沿双极光谱的进展：从双极光谱条件转换为双极I和II疾病的纵向研究。
DOI：
10.1037/a0023973
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发表时间：
2012-02
影响因子：
4.6
通讯作者：
Hogan M
中科院分区：
文献类型：
--
作者：
Alloy LB;Urošević S;Abramson LY;Jager-Hyman S;Nusslock R;Whitehouse WG;Hogan M
很少有纵向研究检查了患有“软”双相情感障碍的个体向更严重的双相情感障碍的进展。我们在一个非患者样本中研究了进展为双相I型和II型诊断的比率和预测因素，该样本为大学年龄的参与者（n = 201），他们具有高的一般行为量表评分，并且在双相谱系纵向调查（LIBS）项目中纵向随访了4.5年的“软”双相谱系障碍的儿童或青少年发作。在57名最初诊断为循环性心境障碍或双相情感障碍的患者中，42.1%进展为双相II型诊断，10.5%进展为双相I型诊断。在144名最初诊断为双相II型的患者中，17.4%进展为双相I型诊断。与来自临床文献和双相情感障碍行为方法系统（BAS）模型的假设一致，并控制相关变量（随访时间、初始抑郁和轻躁狂症状、寻求治疗和家族史），高BAS敏感性（尤其是BAS寻乐趣）预测进展为双相II型障碍的可能性更大，而早期发病和高冲动性预示着更大的进展为双相I型的可能性（当家族史未得到控制时，高BAS敏感性和寻乐趣也预示着进展为双相I型）。高BAS和高行为抑制系统（BIS）敏感性的相互作用也预测了更大的进展为双相I的可能性。我们讨论的双相情感障碍的概念，BAS模型的双相情感障碍，和早期干预工作的研究结果的影响。
Little longitudinal research has examined progression to more severe bipolar disorders in individuals with “soft” bipolar spectrum conditions. We examine rates and predictors of progression to bipolar I and II diagnoses in a non-patient sample of college-age participants (n = 201) with high General Behavior Inventory scores and childhood or adolescent onset of “soft” bipolar spectrum disorders followed longitudinally for 4.5 years from the Longitudinal Investigation of Bipolar Spectrum (LIBS) project. Of 57 individuals with initial cyclothymia or bipolar disorder not otherwise specified (BiNOS) diagnoses, 42.1% progressed to a bipolar II diagnosis and 10.5% progressed to a bipolar I diagnosis. Of 144 individuals with initial bipolar II diagnoses, 17.4% progressed to a bipolar I diagnosis. Consistent with hypotheses derived from the clinical literature and the Behavioral Approach System (BAS) model of bipolar disorder, and controlling for relevant variables (length of follow-up, initial depressive and hypomanic symptoms, treatment-seeking, and family history), high BAS sensitivity (especially BAS Fun Seeking) predicted a greater likelihood of progression to bipolar II disorder, whereas early age of onset and high impulsivity predicted a greater likelihood of progression to bipolar I (high BAS sensitivity and Fun-Seeking also predicted progression to bipolar I when family history was not controlled). The interaction of high BAS and high Behavioral Inhibition System (BIS) sensitivities also predicted greater likelihood of progression to bipolar I. We discuss implications of the findings for the bipolar spectrum concept, the BAS model of bipolar disorder, and early intervention efforts.
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影响因子：
4.4
作者：
Dawe, S;Gullo, MJ;Loxton, NJ
通讯作者：
Loxton, NJ
影响因子：
4.8
作者：
Alloy, Lauren B.;Abramson, Lyn Y.;Nusslock, Robin
通讯作者：
Nusslock, Robin
影响因子：
6.6
作者：
Akiskal, HS;Hantouche, EG;Allilaire, JF
通讯作者：
Allilaire, JF
影响因子：
1.9
作者：
CHAPMAN, LJ;CHAPMAN, JP;BECKFIELD, D
通讯作者：
BECKFIELD, D
影响因子：
5.4
作者：
Beesdo, Katja;Hoefler, Michael;Pfennig, Andrea
通讯作者：
Pfennig, Andrea