An Hsp20-FBXO4 Axis Regulates Adipocyte Function through Modulating PPARγ Ubiquitination.
An Hsp20-FBXO4 Axis Regulates Adipocyte Function through Modulating PPARγ Ubiquitination.
复制标题
DOI：
10.1016/j.celrep.2018.05.065
复制
发表时间：
2018-06-19
期刊：
影响因子：
8.8
通讯作者：
Fan GC
中科院分区：
文献类型：
--
作者：
Peng J;Li Y;Wang X;Deng S;Holland J;Yates E;Chen J;Gu H;Essandoh K;Mu X;Wang B;McNamara RK;Peng T;Jegga AG;Liu T;Nakamura T;Huang K;Perez-Tilve D;Fan GC
Exposure to cold temperature is well known to upregulate heat shock protein (Hsp) expression and recruit and/or activate brown adipose tissue and beige adipocytes in humans and animals. However, whether and how Hsps regulate adipocyte function for energy homeostatic responses is poorly understood. Here, we demonstrate a critical role of Hsp20 as a negative regulator of adipocyte function. Deletion of Hsp20 enhances non-shivering thermogenesis and suppresses inflammatory responses, leading to improvement of glucose and lipid metabolism under both chow diet and high-fat diet conditions. Mechanistically, Hsp20 controls adipocyte function by interacting with the subunit of the ubiquitin ligase complex, F-box only protein 4 (FBXO4), and regulating the ubiquitin-dependent degradation of peroxisome proliferation activated receptor gamma (PPARγ). Indeed, Hsp20 deficiency mimics and enhances the pharmacological effects of the PPARγ agonist rosiglitazone. Together, our findings suggest a role of Hsp20 in mediating adipocyte function by linking β-adrenergic signaling to PPARγ activity. Peng et al. identify a dual function for heat shock protein 20 (Hsp20) in regulating white adipocyte maturation and function through the FBXO4-PPARγ axis. The absence of Hsp20 improves the metabolic profile even under obesity conditions.
登录
查看更多内容
影响因子：
64.8
作者：
通讯作者：
--
影响因子：
29
作者：
Kajimura S;Spiegelman BM;Seale P
通讯作者：
Seale P
影响因子：
20.1
作者：
Fan GC;Zhou X;Wang X;Song G;Qian J;Nicolaou P;Chen G;Ren X;Kranias EG
通讯作者：
Kranias EG
影响因子：
64.5
作者：
Fedorenko A;Lishko PV;Kirichok Y
通讯作者：
Kirichok Y
影响因子：
82.9
作者：
通讯作者：
--