Recent advances in obesity: adiposity signaling and fat metabolism in energy homeostasis.
Recent advances in obesity: adiposity signaling and fat metabolism in energy homeostasis.
复制标题
肥胖的最新进展：能量稳态中的脂肪信号传导和脂肪代谢。
DOI：
10.1159/000090959
复制
发表时间：
2006
影响因子：
--
通讯作者：
Moran,TimothyH
中科院分区：
文献类型：
--
作者：
Aja,Susan;Moran,TimothyH
我们保守的“节俭基因型”与当前减少体力活动和增加食物摄入的趋势之间的相互作用被认为是现代肥胖患病率上升的根本原因。在过去的十年里，我们对能量平衡和肥胖的生理调节的理解取得了巨大的进步，对肥胖的发病机制也有了重要的认识。我们已经获得了一个更全面的观点的能量稳态系统从肥胖激素瘦素的发现，随后确定下丘脑和其他脑神经肽系统控制能量平衡，并在理解细胞可以感知和响应代谢状态的变化的分子机制的进展。许多目标已被确定为潜在的药理学和遗传学方法来控制肥胖。一些最新的发展是操纵外周组织和大脑中的脂肪代谢的原型化合物，以减少身体脂肪合成和储存并增加脂肪氧化，减少食物摄入并增加能量消耗。
Interactions between our conserved ‘thrifty genotype’and current trends toward reduced physical activity and increased food intake are posited as the root cause of the rising prevalence of obesity in the modern era. The past decade has seen tremendous advances in our understanding of the physiological regulation of energy balance and adiposity, and important insights into the pathogenesis of obesity. We have gained a more comprehensive view of the energy homeostasis system from the discovery of the adiposity hormone leptin, the subsequent identification of hypothalamic and other brain neuropeptide systems controlling energy balance, and the progress in understanding the molecular mechanisms by which cells can sense and respond to changes in metabolic state. Numerous targets have been identified for potential pharmacological and genetic approaches to obesity management. Some of the most recent developments are prototypic compounds that manipulate fat metabolism, both in peripheral tissues and in the brain, to reduce body fat synthesis and storage and to increase fat oxidation, to reduce food intake, and to increase energy expenditure.
登录
查看更多内容
DOI：
10.1152/ajpregu.00604.2003
发表时间：
2004-07-01
影响因子：
2.8
作者：
Blevins, JE;Schwartz, MW;Baskin, DG
通讯作者：
Baskin, DG
游离脂肪酸对大鼠下丘脑外侧神经元的影响
影响因子：
2.9
作者：
Y. Oomura;Tsutomu Nakamura;M. Sugimori;Yasuyuki Yamada
通讯作者：
Yasuyuki Yamada
影响因子：
7.7
作者：
Baskin, DG;Breininger, JF;Schwartz, MW
通讯作者：
Schwartz, MW
影响因子：
15.9
作者：
Schwartz, MW;Seeley, RJ;Baskin, DG
通讯作者：
Baskin, DG
影响因子：
4.8
作者：
Harwood, HJ;Petras, SF;Eisenbeis, SA
通讯作者：
Eisenbeis, SA