Neutrophil-to-Lymphocyte Ratio Is a Potential Prognostic Biomarker in Patients with Ovarian Cancer: A Meta-Analysis.
Neutrophil-to-Lymphocyte Ratio Is a Potential Prognostic Biomarker in Patients with Ovarian Cancer: A Meta-Analysis.
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DOI：
10.1155/2017/7943467
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发表时间：
2017
影响因子：
--
通讯作者：
Zhao Y
中科院分区：
文献类型：
--
作者：
Chen S;Zhang L;Yan G;Cheng S;Fathy AH;Yan N;Zhao Y
许多研究探讨了中性粒细胞/淋巴细胞比率(NLR)在卵巢癌预后中的意义，但结果相互矛盾。本研究旨在总结NLR在卵巢癌患者预后中的意义。对PubMed、Cochrane图书馆和Embase进行文献检索。终点为无进展生存期(PFS)和总生存期(OS)。共确定了11项研究，涉及2892名患者。结果表明，卵巢癌中NLR高的患者较NLR低的患者PFS短(HR=1.5 5，95%CI=1.15~2.0 8，p=0.004，I2=61%)。同样，高NLR与较短的OS有关(HR=1.51，95%CI=1.03-2.23，p=0.04，I2=85%)。此外，当NLR截断值小于3.3时(p=0.03时)或治疗为手术时(p=0.002)，高NLR值与较短的PFS显著相关。此外，在亚洲人中，高NLR与较差的OS(p=0.04)或手术(p=0.04)明显相关。在卵巢癌中，高NLR与较短的PFS和OS相关。在卵巢癌患者中，NLR可能是一个很有前途的预后生物标志物。
Plenty of studies were conducted to explore the prognostic significance of neutrophil-to-lymphocyte ratio (NLR) in ovarian cancer with contradictory results. This study aims to summarize the prognostic significance of NLR in patients with ovarian cancer. A literature search in PubMed, Cochrane Library, and Embase was conducted. The endpoints were progression-free survival (PFS) and overall survival (OS). Eleven studies involving a total of 2,892 patients were identified. The results indicated that patients with high NLR had shorter PFS compared to patients with low NLR in ovarian cancer (HR = 1.55, 95% CI = 1.15–2.08, p = 0.004, and I2 = 61%). Similarly, high NLR was related to shorter OS (HR = 1.51, 95% CI = 1.03–2.23, p = 0.04, and I2 = 85%). Moreover, high NLR was significantly associated with shorter PFS when the NLR cut-off was less than 3.3 (p = 0.03) or when treatment is operation (p = 0.002). In addition, high NLR was distinctly related to worse OS in Asian people (p = 0.04) or operation (p = 0.04). High NLR was associated with shorter PFS and shorter OS in ovarian cancer. NLR is potentially a promising prognostic biomarker in patients with ovarian cancer.
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DOI：
10.6061/clinics/2016(06)04
发表时间：
2016-07
期刊：
Clinics (Sao Paulo, Brazil)
影响因子：
--
作者：
Gong W;Yang S;Yang X;Guo F
通讯作者：
Guo F
影响因子：
2.5
作者：
Tierney JF;Stewart LA;Ghersi D;Burdett S;Sydes MR
通讯作者：
Sydes MR
影响因子：
5.3
作者：
Sanchez-Salcedo, Pablo;de-Torres, Juan P.;Zulueta, Javier J.
通讯作者：
Zulueta, Javier J.
嗜中性粒细胞与淋巴细胞比率与阴茎癌患者的疾病特异性死亡率有关。
影响因子：
3.8
作者：
Kasuga J;Kawahara T;Takamoto D;Fukui S;Tokita T;Tadenuma T;Narahara M;Fusayasu S;Terao H;Izumi K;Ito H;Hattori Y;Teranishi J;Sasaki T;Makiyama K;Miyoshi Y;Yao M;Yumura Y;Miyamoto H;Uemura H
通讯作者：
Uemura H
影响因子：
2.9
作者：
Nakamura K;Nagasaka T;Nishida T;Haruma T;Ogawa C;Kusumoto T;Seki N;Hiramatsu Y
通讯作者：
Hiramatsu Y