Oncolytic Viruses-Interaction of Virus and Tumor Cells in the Battle to Eliminate Cancer.
Oncolytic Viruses-Interaction of Virus and Tumor Cells in the Battle to Eliminate Cancer.
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DOI：
10.3389/fonc.2017.00195
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发表时间：
2017
影响因子：
4.7
通讯作者：
Wang Y
中科院分区：
文献类型：
--
作者：
Howells A;Marelli G;Lemoine NR;Wang Y
溶瘤病毒（OVs）是许多癌症类型的新兴治疗选择，最近已成为广泛研究的焦点，旨在开发其治疗潜力。最终目标是设计一种能够在宿主内有效复制的病毒，特异性靶向和裂解肿瘤细胞，并诱导强大、持久的肿瘤特异性免疫。有许多病毒要么天生具有肿瘤选择性，要么可以经过修饰以特异性靶向和消除肿瘤细胞。这意味着它们只能感染肿瘤细胞，而健康组织不会受到伤害。为了减少溶瘤病毒治疗的副作用，这种特异性是必要的。这些病毒也可以通过各种方法进行修饰，包括插入和删除特定基因，目的是提高它们的效力和安全性。在这篇综述中，我们概述了目前正在研究的各种病毒种类的溶瘤潜力，以及用于增加其感染性、抗肿瘤免疫和治疗安全性的多种修饰的正面和负面影响，特别关注肿瘤细胞和OVs的相互作用。
Oncolytic viruses (OVs) are an emerging treatment option for many cancer types and have recently been the focus of extensive research aiming to develop their therapeutic potential. The ultimate aim is to design a virus which can effectively replicate within the host, specifically target and lyse tumor cells and induce robust, long lasting tumor-specific immunity. There are a number of viruses which are either naturally tumor-selective or can be modified to specifically target and eliminate tumor cells. This means they are able to infect only tumor cells and healthy tissue remains unharmed. This specificity is imperative in order to reduce the side effects of oncolytic virotherapy. These viruses can also be modified by various methods including insertion and deletion of specific genes with the aim of improving their efficacy and safety profiles. In this review, we have provided an overview of the various virus species currently being investigated for their oncolytic potential and the positive and negative effects of a multitude of modifications used to increase their infectivity, anti-tumor immunity, and treatment safety, in particular focusing on the interaction of tumor cells and OVs.
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影响因子：
--
作者：
Achard C;Boisgerault N;Delaunay T;Roulois D;Nedellec S;Royer PJ;Pain M;Combredet C;Mesel-Lemoine M;Cellerin L;Magnan A;Tangy F;Grégoire M;Fonteneau JF
通讯作者：
Fonteneau JF
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影响因子：
4.7
作者：
Cheng, Pei-Hsin;Rao, Xiao-Mei;Duan, Xiaoxian;Li, Xiao-Feng;Egger, Michael E.;McMasters, Kelly M.;Zhou, H. Sam
通讯作者：
Zhou, H. Sam
影响因子：
10.8
作者：
Alfonso Rojas, Luis;Condezo, Gabriela N.;Alemany, Ramon
通讯作者：
Alemany, Ramon
影响因子：
5.4
作者：
Berchtold, Susanne;Lampe, Johanna;Lauer, Ulrich M.
通讯作者：
Lauer, Ulrich M.
影响因子：
4.8
作者：
Chia SL;Yusoff K;Shafee N
通讯作者：
Shafee N