Fatigue, inflammation, and projected mortality in heart failure.
Fatigue, inflammation, and projected mortality in heart failure.
复制标题
DOI：
10.1016/j.cardfail.2012.07.003
复制
发表时间：
2012-09
影响因子：
6
通讯作者：
Piano, Mariann R.
中科院分区：
文献类型：
--
作者：
Fink, Anne M.;Gonzalez, Rosalia C.;Lisowski, Tadeusz;Pini, Maria;Fantuzzi, Giamila;Levy, Wayne C.;Piano, Mariann R.
疲劳是心力衰竭伴射血分数降低（HFrEF）的一个突出且鲜为人知的症状。本研究的目的是确定疲劳是否与免疫生物标志物和预后相关。在HFrEF患者（N = 59）和健康对照（N = 25）中，我们前瞻性地测量了疲劳（情绪状态量表）、抑郁症状（患者健康问卷-8）、睡眠质量（匹兹堡睡眠质量指数）和免疫生物标志物（血浆c -反应蛋白[CRP]、肿瘤坏死因子-α [tnf -α]和白细胞介素[IL-6和IL-10]）。测定西雅图心力衰竭模型（SHFM）死亡风险评分。与对照组相比，HFrEF患者明显有更大的疲劳和抑郁症状，睡眠质量更差。然而，当控制抑郁症状时，疲劳在HFrEF患者和对照组之间没有显着差异。与对照组相比，HFrEF患者的IL-10水平显著降低。细胞因子与疲劳无显著相关，但疲劳与较高的SHFM评分显著相关。抑郁症状是HFrEF患者疲劳的重要协变量。我们的研究结果首次显示了疲劳与SHFM评分之间的正相关，表明疲劳与较差的预后相关。
Fatigue is a prominent and poorly understood symptom of heart failure with reduced ejection fraction (HFrEF). The purpose of this study was to determine whether fatigue correlated with immune biomarkers and prognosis. In patients with HFrEF (N = 59) and healthy controls (N = 25), we prospectively measured fatigue (Profile of Mood States), depressive symptoms (Patient Health Questionnaire-8), sleep quality (Pittsburgh Sleep Quality Index), and immune biomarkers (plasma C-reactive protein [CRP], tumor necrosis factor-α [TNFα], and interleukins [IL-6 and IL-10]). Seattle Heart Failure Model (SHFM) mortality risk scores were determined. Patients with HFrEF had significantly greater fatigue and depressive symptoms and poorer sleep quality compared to control subjects. When controlling for depressive symptoms, however, fatigue did not differ significantly between patients with HFrEF and controls. Patients with HFrEF had significantly lower levels of IL-10 compared to controls. Cytokines did not correlate significantly with fatigue, but fatigue was significantly associated with higher SHFM scores. Depressive symptoms were an important covariate of fatigue in patients with HFrEF. Our study findings were the first to show a positive association between fatigue and the SHFM score, indicating that fatigue was associated with poorer prognosis.
登录
查看更多内容
影响因子：
37.8
作者：
Mozaffarian, Dariush;Anker, Stefan D.;Levy, Wayne C.
通讯作者：
Levy, Wayne C.
影响因子：
24
作者：
Kalogeropoulos, Andreas P.;Georgiopoulou, Vasiliki V.;Butler, Javed
通讯作者：
Butler, Javed
影响因子：
8.4
作者：
Jager, A.;Sleijfer, S.;van der Rijt, C. C. D.
通讯作者：
van der Rijt, C. C. D.
影响因子：
6.9
作者：
Addington, AM;Gallo, JJ;Eaton, WW
通讯作者：
Eaton, WW
影响因子：
11.3
作者：
BUYSSE, DJ;REYNOLDS, CF;KUPFER, DJ
通讯作者：
KUPFER, DJ