Neuromodulation of conditioned placebo/nocebo in heat pain: anodal vs cathodal transcranial direct current stimulation to the right dorsolateral prefrontal cortex.
Neuromodulation of conditioned placebo/nocebo in heat pain: anodal vs cathodal transcranial direct current stimulation to the right dorsolateral prefrontal cortex.
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DOI：
10.1097/j.pain.0000000000000163
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发表时间：
2015-07
期刊：
影响因子：
7.4
通讯作者：
Camprodon JA
中科院分区：
文献类型：
--
作者：
Egorova N;Yu R;Kaur N;Vangel M;Gollub RL;Dougherty DD;Kong J;Camprodon JA
安慰剂和反安慰剂在临床实践和医学研究中发挥着重要作用。使用非侵入性脑刺激方法（如经颅直流电刺激（tDCS））调节安慰剂/反安慰剂反应，有可能在临床环境中利用这些效应获得治疗益处。在本研究中，我们评估了阳极和阴极tDCS对右侧DLPFC对热痛的条件安慰剂/反安慰剂线索反应的影响。两组匹配的健康志愿者接受了相同的条件反射训练，在此期间，低和高的线索（抽象图像）分别与低和高的疼痛水平相关。在右侧DLPFC上施加20分钟2 mA tDCS（阳极或阴极）。tDCS电流极性（阳极与阴极）对安慰剂和反安慰剂的影响进行了评估，使用受试者的疼痛评级，以响应之前由条件性高或低提示引起的相同疼痛。提示呈现的持续时间各不相同，以允许完全有意识或阈下处理。显着的安慰剂和nocebo效应在阳极，但不是阴极组引起的条件反射范例。这项研究提供了一种可能性的证据，调节条件安慰剂和反安慰剂效应，通过改变右侧DLPFC的兴奋性，使用tDCS。
Placebo and nocebo play an important role in clinical practice and medical research. Modulating placebo/nocebo responses using noninvasive brain stimulation methods, such as transcranial direct current stimulation (tDCS), has the potential to harness these effects to therapeutic benefit in a clinical setting. In the present study we assessed the effect of anodal and cathodal tDCS over the right DLPFC on conditioned placebo/nocebo cue response to heat pain. Two matched groups of healthy volunteers were subjected to an identical session of conditioning, during which low and high cues (abstract images) were associated with low and high pain levels, respectively. Twenty-minute 2mA tDCS (either anodal or cathodal) over the right DLPFC was applied. The influence of tDCS current polarity (anodal vs. cathodal) on placebo and nocebo was assessed, using subjects’ pain ratings in response to identical pain preceded by the conditioned high or low cues. The duration of cue presentation varied to allow either fully conscious or subliminal processing. Significant placebo and nocebo effects in the anodal but not the cathodal group were elicited with the conditioning paradigm. This study provides evidence of a possibility to modulate the conditioned placebo and nocebo effect by changing the excitability of the right DLPFC using tDCS.
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影响因子：
17.1
作者：
Kam-Hansen S;Jakubowski M;Kelley JM;Kirsch I;Hoaglin DC;Kaptchuk TJ;Burstein R
通讯作者：
Burstein R
影响因子：
5.7
作者：
Craggs, Jason G.;Price, Donald D.;Robinson, Michael M.
通讯作者：
Robinson, Michael M.
影响因子：
16.2
作者：
Eippert, Falk;Bingel, Ulrike;Buechel, Christian
通讯作者：
Buechel, Christian
影响因子：
7.4
作者：
GRACELY, RH;MCGRATH, P;DUBNER, R
通讯作者：
DUBNER, R
影响因子：
4.8
作者：
Amanzio, Martina;Benedetti, Fabrizio;Cauda, Franco
通讯作者：
Cauda, Franco