IFITM proteins incorporated into HIV-1 virions impair viral fusion and spread.
IFITM proteins incorporated into HIV-1 virions impair viral fusion and spread.
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DOI：
10.1016/j.chom.2014.11.001
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发表时间：
2014-12-10
影响因子：
30.3
通讯作者：
Schwartz O
中科院分区：
文献类型：
--
作者：
Compton AA;Bruel T;Porrot F;Mallet A;Sachse M;Euvrard M;Liang C;Casartelli N;Schwartz O
干扰素诱导的跨膜（IFITM）蛋白通过抑制病毒-细胞融合来保护细胞免受各种病毒感染。IFITM蛋白还通过仅部分了解的机制抑制HIV-1复制。我们发现，当在未感染的淋巴细胞中表达时，IFITM蛋白在无细胞病毒感染期间发挥保护作用，但这种限制可以在HIV-1细胞间传播时克服。然而，当存在于产生病毒的淋巴细胞中时，IFITM蛋白与病毒Env和Gag蛋白共定位，并掺入新生的HIV-1病毒体中以限制进入新的靶细胞。病毒膜中的IFITM与受损的病毒体融合有关，提供额外的和更有效的防御病毒传播。因此，IFITM蛋白在有效感染的细胞和未感染的靶细胞中起相加作用以抑制HIV-1传播，潜在地赋予这些蛋白质更大的抗包膜病毒的广度和效力。IFITM蛋白抑制HIV从受感染细胞向新靶细胞的传播IFITM与病毒Env和Gag蛋白共定位并整合到病毒体中当整合到病毒体中时，IFITM蛋白降低病毒颗粒的感染性IFITM在病毒膜中比IFITM在细胞中更有效地削弱病毒体融合干扰素诱导的跨膜（IFITM）蛋白是膜驻留的抗病毒效应物，保护细胞免受各种病毒的感染。Compton等人描述了IFITM蛋白的功能，其中掺入HIV-1病毒体的膜中并抑制病毒和靶细胞之间的融合导致HIV-1传播的有效阻断。
The interferon-induced transmembrane (IFITM) proteins protect cells from diverse virus infections by inhibiting virus-cell fusion. IFITM proteins also inhibit HIV-1 replication through mechanisms only partially understood. We show that when expressed in uninfected lymphocytes, IFITM proteins exert protective effects during cell-free virus infection, but this restriction can be overcome upon HIV-1 cell-to-cell spread. However, when present in virus-producing lymphocytes, IFITM proteins colocalize with viral Env and Gag proteins and incorporate into nascent HIV-1 virions to limit entry into new target cells. IFITM in viral membranes is associated with impaired virion fusion, offering additional and more potent defense against virus spread. Thus, IFITM proteins act additively in both productively infected cells and uninfected target cells to inhibit HIV-1 spread, potentially conferring these proteins with greater breadth and potency against enveloped viruses. IFITM proteins inhibit HIV spread from infected cells to new target cells IFITM colocalize with viral Env and Gag proteins and incorporate into virions When incorporated into virions, IFITM proteins reduce virus particle infectivity IFITM in viral membranes impair virion fusion more potently than IFITM in cells Interferon-induced transmembrane (IFITM) proteins are membrane-resident antiviral effectors, protecting cells against infection by diverse viruses. Compton et al. describe a function for IFITM proteins in which incorporation into the membrane of HIV-1 virions and inhibition of fusion between virus and target cell lead to a potent block of HIV-1 spread.
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影响因子：
5.8
作者：
Chutiwitoonchai N;Hiyoshi M;Hiyoshi-Yoshidomi Y;Hashimoto M;Tokunaga K;Suzu S
通讯作者：
Suzu S
影响因子：
6.7
作者：
Casartelli N;Sourisseau M;Feldmann J;Guivel-Benhassine F;Mallet A;Marcelin AG;Guatelli J;Schwartz O
通讯作者：
Schwartz O
DOI：
10.1083/jcb.200609050
发表时间：
2007-04-23
期刊：
The Journal of cell biology
影响因子：
--
作者：
Deneka M;Pelchen-Matthews A;Byland R;Ruiz-Mateos E;Marsh M
通讯作者：
Marsh M
鉴定 IFITM3 抗病毒作用所必需的内吞信号。
影响因子：
3.4
作者：
Jia R;Xu F;Qian J;Yao Y;Miao C;Zheng YM;Liu SL;Guo F;Geng Y;Qiao W;Liang C
通讯作者：
Liang C
影响因子：
30.3
作者：
Amini-Bavil-Olyaee S;Choi YJ;Lee JH;Shi M;Huang IC;Farzan M;Jung JU
通讯作者：
Jung JU