Measurement of Frontal Midline Theta Oscillations using OPM-MEG.
Measurement of Frontal Midline Theta Oscillations using OPM-MEG.
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DOI：
10.1016/j.neuroimage.2023.120024
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发表时间：
2023-05-01
期刊：
影响因子：
5.7
通讯作者：
Brookes, Matthew J.
中科院分区：
文献类型：
--
作者：
Rhodes, Natalie;Rea, Molly;Boto, Elena;Rier, Lukas;Shah, Vishal;Hill, Ryan M.;Osborne, James;Doyle, Cody;Holmes, Niall;Coleman, Sebastian C.;Mullinger, Karen;Bowtell, Richard;Brookes, Matthew J.
关键词：
光泵磁强计(OPM)是一种新兴的轻便紧凑的传感器，可以测量人脑产生的磁场。OPM使可穿戴式脑磁图(MEG)系统的构建成为可能，该系统具有传统仪器无法比拟的优势。然而，当试图在低频下测量信号时，较高水平的固有传感器噪声、磁干扰和运动伪影带来了巨大的挑战。低频脑信号的准确特征对于神经科学、临床和儿科脑磁图的应用非常重要，因此，证明OPM在这一领域的可行性是至关重要的。在这里，我们进行了theta频段(4-8赫兹)神经振荡的测量，并将新开发的174通道三轴可穿戴OPM-MEG系统与传统的(低温-MEG)仪器进行了对比。我们的结果表明，使用OPM-MEG可以记录到4赫兹、6赫兹和8赫兹的视觉稳态响应，其信噪比(SNR)与传统的脑磁图没有显著差异。此外，我们在2-back工作记忆任务中测量了正面中线theta振荡，再次证明了两个系统的信噪比相当。我们表明，诱发额中线theta反应的幅度和空间特征的个体差异在不同系统之间保持不变。最后，我们证明，如果没有三轴传感器阵列或后处理技术的使用，我们的OPM-MEG结果是不可能实现的。我们的结果证明了OPMS在表征theta振荡方面的可行性，并增加了OPMS可以取代低温传感器作为MEG系统基本构件的论点的份量。
Optically pumped magnetometers (OPMs) are an emerging lightweight and compact sensor that can measure magnetic fields generated by the human brain. OPMs enable construction of wearable magnetoencephalography (MEG) systems, which offer advantages over conventional instrumentation. However, when trying to measure signals at low frequency, higher levels of inherent sensor noise, magnetic interference and movement artefact introduce a significant challenge. Accurate characterisation of low frequency brain signals is important for neuroscientific, clinical, and paediatric MEG applications and consequently, demonstrating the viability of OPMs in this area is critical. Here, we undertake measurement of theta band (4–8 Hz) neural oscillations and contrast a newly developed 174 channel triaxial wearable OPM-MEG system with conventional (cryogenic-MEG) instrumentation. Our results show that visual steady state responses at 4 Hz, 6 Hz and 8 Hz can be recorded using OPM-MEG with a signal-to-noise ratio (SNR) that is not significantly different to conventional MEG. Moreover, we measure frontal midline theta oscillations during a 2-back working memory task, again demonstrating comparable SNR for both systems. We show that individual differences in both the amplitude and spatial signature of induced frontal-midline theta responses are maintained across systems. Finally, we show that our OPM-MEG results could not have been achieved without a triaxial sensor array, or the use of postprocessing techniques. Our results demonstrate the viability of OPMs for characterising theta oscillations and add weight to the argument that OPMs can replace cryogenic sensors as the fundamental building block of MEG systems.
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