Effectiveness of orthotopic liver transplantation on the restoration of cholesterol metabolism in patients with end-stage liver disease.
Effectiveness of orthotopic liver transplantation on the restoration of cholesterol metabolism in patients with end-stage liver disease.
复制标题
原位肝移植对终末期肝病患者胆固醇代谢恢复的有效性。
DOI：
10.1016/0016-5085(87)90241-1
复制
发表时间：
1987
期刊：
影响因子：
29.4
通讯作者：
Bistrian,BR
中科院分区：
文献类型：
--
作者：
Palombo,JD;Lopes,SM;Zeisel,SH;Jenkins,RL;Albers,JJ;Blackburn,GL;Bistrian,BR
评估了终末期肝病和原位肝移植对调节血浆胆固醇酯化的成分的影响。与健康对照组相比，终末期肝病患者的卵磷脂-胆固醇酰基转移酶质量、载脂蛋白A-1、总磷脂、总胆固醇和酯化胆固醇的浓度均显著降低。升高的磷脂酰胆碱和降低的溶血磷脂酰胆碱组分表明卵磷脂-胆固醇酰基转移酶对胆固醇酯化的损害。患者的磷脂和胆固醇酯的组成脂肪酸表现为饱和度增加和多不饱和脂肪酸的减少，这表明肝脏伸长和必需脂肪酸的降低。肝移植术后3个月，血浆总胆固醇、磷脂、卵磷脂-胆固醇酰基转移酶、载脂蛋白A-1浓度与健康人相当。6个月时，尽管胆固醇酯化作用增强，参与这一过程的酶和辅因子迅速恢复正常，但磷脂酰胆碱的百分比仍显著高于正常对照组，而溶血磷脂酰胆碱和酯化胆固醇的百分比仍显著低于健康对照组。移植后6个月，磷脂和胆固醇酯脂肪酸模式恢复正常。我们的结论是，肝移植有效地恢复了终末期肝病患者的胆固醇和必需脂肪酸代谢。
The effects of end-stage liver disease and orthotopic liver transplantation on components that modulate cholesterol esterification in plasma were assessed. In comparison with healthy controls, patients with end-stage liver disease had significantly decreased concentrations of lecithin-cholesterol acyltransferase mass, apolipoprotein A-1, total phospholipids, and both total and esterified cholesterol. Elevated phosphatidylcholine and reduced lysophosphatidylcholine fractions indicated impairment of cholesterol esterification by lecithin-cholesterol acyltransferase. Constituent fatty acids of the patients' phospholipids and cholesterol esters manifested increased saturation and a concomitant reduction of polyunsaturated fatty acids, indicative of impaired hepatic elongation and desaturation of essential fatty acids. By the third month after hepatic replacement, the plasma concentrations of total cholesterol, phospholipids, lecithin-cholesterol acyltransferase, and apolipoprotein A-1 were comparable to those of the healthy subjects. Despite the improvement in cholesterol esterification and the rapid normalization of the enzyme and cofactor involved in this process, the percentage of phosphatidylcholine remained significantly higher and the percentages of lysophosphatidylcholine and esterified cholesterol remained significantly lower than in the healthy subjects at 6 mo. Phospholipid and cholesterol ester fatty acid patterns attained normalcy by the sixth month after transplant. We conclude that hepatic transplantation effectively restores cholesterol and essential fatty acid metabolism in patients with end-stage liver disease.
登录
查看更多内容
肝病患者脂蛋白胆固醇酯代谢的体内评价
影响因子：
29.4
作者：
P. Monroe;Z. Vlahcevic;L. Swell
通讯作者：
L. Swell
DOI：
10.3109/00365516609051816
发表时间：
1966
影响因子：
2.1
作者：
E. Gjone;O. Orning
通讯作者：
O. Orning
肝脏疾病中的血清胆固醇酯化。
DOI：
10.1056/nejm197010152831604
发表时间：
1970
期刊：
The New England journal of medicine
影响因子：
--
作者：
J. B. Simon;R. Scheig
通讯作者：
R. Scheig
卵磷脂的磷脂酰胆碱底物特异性：胆固醇酰基转移酶。
DOI：
10.1080/00365517809104894
发表时间：
1978
期刊：
Scandinavian journal of clinical and laboratory investigation. Supplementum
影响因子：
--
作者：
G. Assmann;G. Schmitz;N. Donáth;D. Lekim
通讯作者：
D. Lekim
各种巯基试剂对卵磷脂：胆固醇酰基转移酶活性的影响对比。
DOI：
--
发表时间：
1981
期刊：
Biochemical and Biophysical Research Communications - BBRC
影响因子：
--
作者：
R. Verdery
通讯作者：
R. Verdery