Production of nitric oxide (NO) in intrathoracic airways of normal humans.
Production of nitric oxide (NO) in intrathoracic airways of normal humans.
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正常人胸腔内气道中一氧化氮（NO）的产生。
DOI：
10.1164/ajrccm.154.5.8912750
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发表时间：
1996
影响因子：
24.7
通讯作者：
Y. Kawakami
中科院分区：
文献类型：
--
作者：
I. Tsujino;K. Miyamoto;M. Nishimura;H. Shinano;H. Makita;Shunichi Saito;Tsuyoshi Nakano;Y. Kawakami
To gain insight into the source of exhaled nitric oxide (NO) in normal humans, we examined the effects of respiratory pattern on the concentration of NO in exhaled air while subjects were wearing a noseclip and then under endotracheal intubation, using a specially designed gas sampling system to separate exhaled air into two fractions: the initially exhaled 200 ml (Fraction 1; F1), and the remainder (Fraction 2; F2). We also examined the effect of hypoxic gas inhalation (F(I)O2 = 0.1, 3 min) on the concentration of exhaled NO. The concentration of exhaled NO measured with a chemiluminescence NO analyzer was significantly lower with intubation, by 59.2 +/- 10.6% (mean +/- SD) (F1) and 54.4 +/- 8.0% (F2), than without intubation. The concentration of NO in F1 was consistently higher than that in F2 with or without intubation. With breath holding, the concentration of NO increased markedly only in F1. In contrast, prolongation of the expiratory phase slightly but significantly increased the concentration of NO only in F2. Inhalation of hypoxic gas did not cause any significant change in NO concentration in either fraction. These data indicate that in normal humans wearing a noseclip, about 40 to 45% of NO in exhaled air originates from the lungs, particularly from intrathoracic airways. The concentration of exhaled NO collected from subjects wearing a noseclip is not affected by hypoxic gas inhalation.
缺氧会增强一氧化氮的合成并短暂增加肺动脉内皮细胞中的胞质钙水平。
DOI：
--
发表时间：
1995
期刊：
The European respiratory journal
影响因子：
--
作者：
Hampl,V;Cornfield,DN;Cowan,NJ;Archer,SL
通讯作者：
Archer,SL
O2 和大鼠肺动脉张力：内皮、Ca2、氰化物和野百合碱的影响。
DOI：
10.1152/jappl.1991.71.1.30
发表时间：
1991
期刊：
Journal of applied physiology (Bethesda, Md. : 1985)
影响因子：
--
作者：
Mathew,R;Burke-Wolin,T;Gewitz,MH;Wolin,MS
通讯作者：
Wolin,MS
分级运动对人体呼出空气中一氧化氮的影响。
DOI：
10.1016/0034-5687(94)90069-8
发表时间：
1994
期刊：
Respiration physiology
影响因子：
--
作者：
Iwamoto,J;Pendergast,DR;Suzuki,H;Krasney,JA
通讯作者：
Krasney,JA