Adaptation of cells to new environments.

Adaptation of cells to new environments.
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DOI:
10.1002/wsbm.136
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发表时间:
2011-09
影响因子:
7.9
通讯作者:
Baliga, Nitin S.
Baliga, Nitin S.
中科院分区:
医学3区
文献类型:
--
作者:
Brooks, Aaron N.;Turkarslan, Serdar;Beer, Karlyn D.;Lo, Fang Yin;Baliga, Nitin S.

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生物体的进化成功证明了其与短期和长期变化的环境条件保持同步的固有能力。适应性过程的潜在机制正在以新的兴趣和兴奋进行研究。这种复兴在一定程度上是由强大的技术推动的,这些技术可以在系统规模上探测分子现象。这些研究提供了对适应机制的深刻见解,包括通过水平基因转移的自然选择、基因复制、删除、动力学参数的重新调整以及无数其他遗传重组事件来重新连接调控网络。在这里,我们将从进化原理的角度讨论原核系统生物学的进展,这些原理塑造了动态适应环境变化的调节网络。
The evolutionary success of an organism is a testament to its inherent capacity to keep pace with environmental conditions that change over short and long periods. Mechanisms underlying adaptive processes are being investigated with renewed interest and excitement. This revival is partly fueled by powerful technologies that can probe molecular phenomena at a systems scale. Such studies provide spectacular insight into the mechanisms of adaptation, including rewiring of regulatory networks via natural selection of horizontal gene transfers, gene duplication, deletion, readjustment of kinetic parameters, and myriad other genetic reorganizational events. Here, we will discuss advances in prokaryotic systems biology from the perspective of evolutionary principles that have shaped regulatory networks for dynamic adaptation to environmental change.
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