Dysfunctional high-density lipoprotein and the potential of apolipoprotein A-1 mimetic peptides to normalize the composition and function of lipoproteins.
Dysfunctional high-density lipoprotein and the potential of apolipoprotein A-1 mimetic peptides to normalize the composition and function of lipoproteins.
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DOI：
10.1253/circj.cj-11-0460
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Reddy ST
中科院分区：
文献类型：
--
作者：
Imaizumi S;Navab M;Morgantini C;Charles-Schoeman C;Su F;Gao F;Kwon M;Ganapathy E;Meriwether D;Farias-Eisner R;Fogelman AM;Reddy ST
尽管在大型流行病学研究中高密度脂蛋白-胆固醇（HDL- c）水平与冠心病（CHD）风险呈负相关，但增加循环HDL- c水平并不一定会降低冠心病事件、冠心病死亡或死亡率的风险，HDL可以作为抗炎分子或促炎分子，这取决于背景和环境。根据最近的一些研究，似乎HDL的抗炎或促炎性质可能比HDL- c水平更敏感地指示动脉粥样硬化的存在或不存在。高密度脂蛋白蛋白质组被认为是冠心病的一个标志，也许是一个中介。载脂蛋白a -1 （apoA-I）是HDL中的主要蛋白，是髓过氧化物酶氧化的选择性靶点，导致HDL功能受损。通过改变其脂质和/或蛋白质含量来改善HDL功能可能是治疗冠心病和许多炎症性疾病的治疗靶点。HDL/apoA-I模拟肽可能有能力改变HDL的脂质和蛋白质含量，并将功能失调的HDL转化为功能正常的HDL。本文综述了动物模型和人类疾病中功能失调的HDL的最新研究，以及apoA-I模拟肽对脂蛋白组成和功能正常化的潜力。
Although high-density lipoprotein-cholesterol (HDL-C) levels in large epidemiological studies are inversely related to the risk of coronary heart disease (CHD), increasing the level of circulating HDL-C does not necessarily decrease the risk of CHD events, CHD deaths, or mortality, HDL can act as an anti- or a proinflammatory molecule, depending on the context and environment. Based on a number of recent studies, it appears that the anti- or proinflammatory nature of HDL may be a more sensitive indicator of the presence or absence of atherosclerosis than HDL-C levels. The HDL proteome has been suggested to be a marker, and perhaps a mediator, of CHD. Apolipoprotein A-1 (apoA-I), the major protein in HDL is a selective target for oxidation by myeloperoxidase, which results in impaired HDL function. Improving HDL function through modification of its lipid and/or protein content maybe a therapeutic target for the treatment of CHD and many inflammatory disorders. HDL/apoA-I mimetic peptides may have the ability to modify the lipid and protein content of HDL and convert dysfunctional HDL to functional HDL. This review focuses on recent studies of dysfunctional HDL in animal models and human disease, and the potential of apoA-I mimetic peptides to normalize the composition and (function of lipoproteins.
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影响因子：
6
作者：
DeLeve, Laurie D.;Wang, Xiangdong;McCuskey, Robert S.
通讯作者：
McCuskey, Robert S.
影响因子：
37.8
作者：
Kruger, AL;Peterson, S;Abraham, NG
通讯作者：
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DOI：
10.1073/pnas.2033602100
发表时间：
2003-10-14
影响因子：
11.1
作者：
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Farias-Eisner, R
影响因子：
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作者：
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影响因子：
3.3
作者：
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