Impaired natural immunity, cognitive dysfunction, and physical symptoms in patients with chronic fatigue syndrome: preliminary evidence for a subgroup?
Impaired natural immunity, cognitive dysfunction, and physical symptoms in patients with chronic fatigue syndrome: preliminary evidence for a subgroup?
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慢性疲劳综合征患者的自然免疫力受损、认知功能障碍和身体症状：亚组的初步证据？
DOI：
10.1016/j.jpsychores.2006.03.001
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发表时间：
2006
影响因子：
4.7
通讯作者：
Klimas,Nancy
中科院分区：
文献类型：
--
作者：
Siegel,ScottD;Antoni,MichaelH;Fletcher,MaryAnn;Maher,Kevin;Segota,MaryCatherine;Klimas,Nancy
OBJECTIVEThe diagnostic criteria of chronic fatigue syndrome (CFS) define a heterogeneous population composed of several subgroups. Past efforts to identify subgroup markers have met with mixed success. This study was designed to examine natural killer cell activity (NKCA) as a potential subgroup marker by comparing the clinical presentations of CFS patients with and without clinically reduced NKCA.METHODSForty-one female CFS patients were classified into having either low or normal NKCA levels. These subgroups were then compared on objective measures of cognitive functioning and subjective assessments of fatigue, vigor, cognitive impairment, and daytime dysfunction.RESULTSRelative to CFS patients in the normal-NKCA subgroup, low-NKCA patients reported less vigor, more daytime dysfunction, and more cognitive impairment. In addition, low-NKCA patients performed less on objective measures of cognitive functioning relative to normal-NKCA patients.CONCLUSIONSThe results are offered as preliminary evidence in support of using NKCA as an immunological subgroup marker in CFS. Findings are also discussed in terms of known associations between dysregulated immune functions, somatic symptoms, and psychological stress.
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DOI：
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发表时间：
1997-02
期刊：
The Journal of rheumatology
影响因子：
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作者：
D. Buchwald;M. Wener;T. Pearlman;P. Kith
通讯作者：
D. Buchwald;M. Wener;T. Pearlman;P. Kith
影响因子：
5
作者：
COHEN, S;KAMARCK, T;MERMELSTEIN, R
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MERMELSTEIN, R
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DOI：
--
发表时间：
2000
期刊：
影响因子：
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作者：
B. Hurwitz;K. Brownley;M. Fletcher;N. Klimas
通讯作者：
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影响因子：
4.6
作者：
Sairenji,T;Yamanishi,K;Tachibana,Y;Bertoni,G;Kurata,T
通讯作者：
Kurata,T
DOI：
--
发表时间：
2002
期刊：
--
影响因子：
--
作者：
N. Rose;R. Hamilton;B. Detrick
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N. Rose;R. Hamilton;B. Detrick