Retrieval of transmembrane proteins to the endoplasmic reticulum.
Retrieval of transmembrane proteins to the endoplasmic reticulum.
复制标题
DOI：
10.1083/jcb.121.2.317
复制
发表时间：
1993-04
期刊：
影响因子：
--
通讯作者：
Peterson PA
中科院分区：
文献类型：
--
作者：
Jackson MR;Nilsson T;Peterson PA
A COOH-terminal double lysine motif maintains type I transmembrane proteins in the ER. Proteins tagged with this motif, eg., CD8/E19 and CD4/E19, rapidly receive post-translational modifications characteristic of the intermediate compartment and partially colocalized to this organelle. These proteins also received modifications characteristic of the Golgi but much more slowly. Lectin staining localized these Golgi modified proteins to ER indicating that this motif is a retrieval signal. Differences in the subcellular distribution and rate of post-translational modification of CD8 maintained in the ER by sequences derived from a variety of ER resident proteins suggested that the efficiency of retrieval was dependent on the sequence context of the double lysine motif and that retrieval may be initiated from multiple positions along the exocytotic pathway.
登录
查看更多内容
影响因子：
4.1
作者：
JACKSON, MR;MCCARTHY, LR;BURCHELL, B
通讯作者：
BURCHELL, B
影响因子：
64.8
作者：
LEWIS, MJ;PELHAM, HRB
通讯作者：
PELHAM, HRB
影响因子：
64.8
作者：
HSU, VW;YUAN, LC;KLAUSNER, RD
通讯作者：
KLAUSNER, RD
影响因子：
64.5
作者：
BECKERS, CJM;KELLER, DS;BALCH, WE
通讯作者：
BALCH, WE
影响因子：
11.4
作者：
JACKSON, MR;NILSSON, T;PETERSON, PA
通讯作者：
PETERSON, PA