The infant gut bacterial microbiota and risk of pediatric asthma and allergic diseases.
The infant gut bacterial microbiota and risk of pediatric asthma and allergic diseases.
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DOI：
10.1016/j.trsl.2016.06.010
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发表时间：
2017-01
期刊：
影响因子：
--
通讯作者：
Ownby DR
中科院分区：
文献类型：
--
作者：
Johnson CC;Ownby DR
在许多领域正在革命性的最近引入的文化独立的微生物鉴定技术是调查与大型动物，抗生素，母乳喂养，出生方式，以及其他暴露在婴儿期与哮喘和过敏性疾病的风险降低之间的关系。这些接触最初被归类在“卫生假说”之下，后来演变为“微生物群假说”。本文首先总结了流行病学研究，这些过敏风险相关暴露的共同特征是它们对儿童肠道微生物群的建立和早期发育的影响。接下来的研究使用独立于培养物的技术，表明经历过感兴趣的暴露的儿童的微生物群改变了肠道微生物群。最后，选定的小鼠和人类的研究，开始证实了流行病学研究中确定的保护性暴露，通过确定微生物可以改变免疫发育和功能的机制。这些微生物驱动的免疫改变表明，在许多情况下，微生物暴露可能会改变随后过敏性疾病和哮喘的风险。希望更好地了解微生物如何影响过敏性疾病将导致安全有效的方法，以减少各种形式的过敏性疾病的患病率。
Among the many areas being revolutionized by the recent introduction of culture independent microbial identification techniques is investigation of the relationship between close contact with large animals, antibiotics, breast feeding, mode of birth, and other exposures during infancy as related to a reduced risk of asthma and allergic disease. These exposures were originally clustered under the “Hygiene Hypothesis” which has morphed into the “Microbiota Hypothesis”. This review begins by summarizing epidemiologic studies suggesting that the common feature of these allergy risk-related exposures is their influence on the founding and early development of a child's gut microbiota. Next studies using culture independent techniques are presented showing that the microbiota of children who have experienced the exposures of interest have altered gut microbiota. Finally, selected mouse and human studies are presented which begin to corroborate the protective exposures identified in epidemiologic studies by identifying mechanisms through which microbes can alter immune development and function. These microbially driven immune alterations demonstrate that microbial exposures in many cases could alter the risk of subsequent allergic disease and asthma. Hopefully a better understanding of how microbes influence allergic disease will lead to safe and effective methods for reducing the prevalence of all forms of allergic disease.
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DOI：
10.1186/1710-1492-9-15
发表时间：
2013
期刊：
Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology
影响因子：
--
作者：
Azad MB;Konya T;Maughan H;Guttman DS;Field CJ;Sears MR;Becker AB;Scott JA;Kozyrskyj AL
通讯作者：
Kozyrskyj AL
DOI：
10.1111/j.1365-2222.2012.04021.x
发表时间：
2012-09
期刊：
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
影响因子：
--
作者：
Almqvist C;Cnattingius S;Lichtenstein P;Lundholm C
通讯作者：
Lundholm C
影响因子：
17.1
作者：
Arrieta, Marie-Claire;Stiemsma, Leah T.;Finlay, B. Brett
通讯作者：
Finlay, B. Brett
影响因子：
158.5
作者：
Bisgaard, Hans;Hermansen, Mette Northman;Pipper, Christian Bressen
通讯作者：
Pipper, Christian Bressen
影响因子：
2.4
作者：
Bentley JP;Simpson JM;Bowen JR;Morris JM;Roberts CL;Nassar N
通讯作者：
Nassar N