Infant gut microbiota and the hygiene hypothesis of allergic disease: impact of household pets and siblings on microbiota composition and diversity.
Infant gut microbiota and the hygiene hypothesis of allergic disease: impact of household pets and siblings on microbiota composition and diversity.
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DOI：
10.1186/1710-1492-9-15
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Kozyrskyj AL
中科院分区：
文献类型：
--
作者：
Azad MB;Konya T;Maughan H;Guttman DS;Field CJ;Sears MR;Becker AB;Scott JA;Kozyrskyj AL
多项研究表明，早期接触宠物或兄弟姐妹可以预防过敏性疾病;这些相关性通常归因于“卫生假说”。最近，婴儿肠道微生物群的低多样性也与过敏性疾病有关。在这项研究中，我们描述了婴儿肠道微生物群与宠物和兄弟姐妹的关系。研究人群包括来自加拿大健康婴儿纵向发育（CHILD）出生队列的24名健康足月婴儿的小样本。母亲们报告了家庭宠物和兄弟姐妹的情况。在4月龄时收集粪便样品，并通过高通量特征基因测序来表征微生物群组成。与宠物生活在一起的婴儿的微生物群丰富度和多样性往往会增加，而这些指标在有年长兄弟姐妹的婴儿中则会减少。与宠物生活在一起的婴儿表现出双歧杆菌科的代表性不足，消化链球菌科的代表性过高;与年长的兄弟姐妹一起生活的婴儿表现出消化链球菌科的代表性不足。这项研究提供了新的证据，表明接触宠物和兄弟姐妹可能会影响肠道微生物群的早期发育，对过敏性疾病有潜在的影响。这两个传统的保护性“卫生假说”因素似乎对肠道微生物群的组成和多样性产生了不同的影响，这使得人们对这些措施的临床意义提出了质疑。需要进一步的研究来证实和扩大这些发现。
Multiple studies have demonstrated that early-life exposure to pets or siblings affords protection against allergic disease; these associations are commonly attributed to the “hygiene hypothesis”. Recently, low diversity of the infant gut microbiota has also been linked to allergic disease. In this study, we characterize the infant gut microbiota in relation to pets and siblings. The study population comprised a small sub-sample of 24 healthy, full term infants from the Canadian Healthy Infant Longitudinal Development (CHILD) birth cohort. Mothers reported on household pets and siblings. Fecal samples were collected at 4 months of age, and microbiota composition was characterized by high-throughput signature gene sequencing. Microbiota richness and diversity tended to be increased in infants living with pets, whereas these measures were decreased in infants with older siblings. Infants living with pets exhibited under-representation of Bifidobacteriaceae and over-representation of Peptostreptococcaceae; infants with older siblings exhibited under-representation of Peptostreptococcaceae. This study provides new evidence that exposure to pets and siblings may influence the early development of the gut microbiota, with potential implications for allergic disease. These two traditionally protective “hygiene hypothesis” factors appear to differentially impact gut microbiota composition and diversity, calling into question the clinical significance of these measures. Further research is required to confirm and expand these findings.
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影响因子：
3.7
作者：
Lødrup Carlsen KC;Roll S;Carlsen KH;Mowinckel P;Wijga AH;Brunekreef B;Torrent M;Roberts G;Arshad SH;Kull I;Krämer U;von Berg A;Eller E;Høst A;Kuehni C;Spycher B;Sunyer J;Chen CM;Reich A;Asarnoj A;Puig C;Herbarth O;Mahachie John JM;Van Steen K;Willich SN;Wahn U;Lau S;Keil T;GALEN WP 1.5 ‘Birth Cohorts’ working group
通讯作者：
GALEN WP 1.5 ‘Birth Cohorts’ working group
影响因子：
3.7
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通讯作者：
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影响因子：
14.2
作者：
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通讯作者：
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影响因子：
2.3
作者：
Bezirtzoglou, Eugenia;Tsiotsias, Arsenis;Welling, Gjalt W.
通讯作者：
Welling, Gjalt W.
影响因子：
14.6
作者：
Azad, Meghan B.;Konya, Theodore;Kozyrskyj, Anita L.
通讯作者：
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