Subcortical volume reduction and cortical thinning 3 months after switching to clozapine in treatment resistant schizophrenia.
Subcortical volume reduction and cortical thinning 3 months after switching to clozapine in treatment resistant schizophrenia.
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DOI：
10.1038/s41537-022-00230-2
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发表时间：
2022-03-02
期刊：
影响因子：
--
通讯作者：
Egerton A
中科院分区：
文献类型：
--
作者：
Krajner F;Hadaya L;McQueen G;Sendt KV;Gillespie A;Avila A;Lally J;Hedges EP;Diederen K;Howes OD;Barker GJ;Lythgoe DJ;Kempton MJ;McGuire P;MacCabe JH;Egerton A
氯氮平的神经生物学作用尚不清楚。我们检查了氯氮平治疗对皮质下体积和皮质厚度的影响，并研究了宏观结构的改变是否与谷氨酸或n -乙酰天冬氨酸（NAA）的改变有关。对24例难治性精神分裂症患者在改用氯氮平前和改用氯氮平后12周的数据进行了分析。在氯氮平治疗期间，我们观察到尾状核和壳核体积减少，侧脑室增大（P < 0.001），左侧下颞叶皮层，左侧尾状中额叶皮层和右侧颞极厚度减少。右侧尾状核体积减少与局部NAA减少相关（P = 0.002）。形态学变化与谷氨酸水平变化无关。这些结果表明氯氮平治疗与皮质下体积损失和皮质变薄有关，至少其中一些影响与神经元或代谢完整性的改变有关。
The neurobiological effects of clozapine are under characterised. We examined the effects clozapine treatment on subcortical volume and cortical thickness and investigated whether macrostructural changes were linked to alterations in glutamate or N-acetylaspartate (NAA). Data were acquired in 24 patients with treatment-resistant schizophrenia before and 12 weeks after switching to clozapine. During clozapine treatment we observed reductions in caudate and putamen volume, lateral ventricle enlargement (P < 0.001), and reductions in thickness of the left inferior temporal cortex, left caudal middle frontal cortex, and the right temporal pole. Reductions in right caudate volume were associated with local reductions in NAA (P = 0.002). None of the morphometric changes were associated with changes in glutamate levels. These results indicate that clozapine treatment is associated with subcortical volume loss and cortical thinning and that at least some of these effects are linked to changes in neuronal or metabolic integrity.
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DOI：
10.1176/appi.ajp.2013.12050674
发表时间：
2013-06
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Andreasen NC;Liu D;Ziebell S;Vora A;Ho BC
通讯作者：
Ho BC
影响因子：
7.6
作者：
Ahmed, Mohamed;Cannon, Dara M.;McDonald, Colm
通讯作者：
McDonald, Colm
影响因子：
3.4
作者：
Deng, Michelle Y.;McAlonan, Grainne M.;Chua, Siew E.
通讯作者：
Chua, Siew E.
影响因子：
4.5
作者：
Di Sero, Alessia;Jorgensen, Kjetil N.;Agartz, Ingrid
通讯作者：
Agartz, Ingrid
影响因子：
2.3
作者：
DeLisi, LE;Sakuma, M;Hoff, AL
通讯作者：
Hoff, AL