Could 3D bioprinted tissues offer future hope for microtia treatment?
Could 3D bioprinted tissues offer future hope for microtia treatment?
复制标题
3D生物打印组织能否为小耳症治疗带来未来希望？
DOI：
10.1016/j.ijsu.2016.06.036
复制
发表时间：
2016
影响因子：
15.3
通讯作者：
Daniel J. Thomas
中科院分区：
文献类型：
--
作者：
Daniel J. Thomas
小耳症是一种耳廓发育不全的先天性畸形。小耳畸形重建的肋骨手术禁忌症包括高危手术状态和胸壁畸形[1-2]。然而，基于干细胞的 3D 生物打印确实为患有此类组织异常的患者提供了革命性的治疗选择。作为一种技术，3D 生物打印技术正在开发中，通过沉积低粘度的可打印细胞活性凝胶并成熟为组织来生成均质组织 [3]。目前正在进行的研究正在开发生产用于重建手术的软骨组织的工艺。该过程的重点是利用细胞的自然自组织特性来产生具有可测量的功能组织：机械、代谢和功能特性。
Microtia is a congenital deformity where the pinna is underdeveloped. Contraindications to rib surgery for microtia reconstruction include high-risk surgical status and chest-wall deformities [1–2]. However does stem-cell-based 3D Bioprinting offer revolutionary therapeutic options for patients with such tissue abnormalities. As a technology, 3D-bioprinting is being developed to generate homogeneous tissues by depositing a low viscosity printable cellular-active gel which matures into a tissue [3]. Currently on-going research is developing the process towards producing cartilage tissues for use in reconstructive surgery. This process focuses on using the natural self-organising properties of cells in order to produce a functional tissue which has measurable: mechanical, metabolic and functional properties.
影响因子：
14
作者：
Lee, Vivian K.;Kim, Diana Y.;Ngo, Haygan;Lee, Young;Seo, Lan;Yoo, Seung-Schik;Vincent, Peter A.;Dai, Guohao
通讯作者：
Dai, Guohao