Cerebral autoregulation in children during sevoflurane anaesthesia.
Cerebral autoregulation in children during sevoflurane anaesthesia.
复制标题
七氟烷麻醉期间儿童的大脑自动调节。
DOI：
10.1093/bja/aeg119
复制
发表时间：
2003
影响因子：
9.8
通讯作者：
Arthur M. Lam
中科院分区：
文献类型：
--
作者：
M. Vavilala;Lorri A. Lee;M. Lee;A. Graham;E. Visco;Arthur M. Lam
介绍
对儿童大脑的自动调节知之甚少。本研究的目的是检查儿童的大脑自动调节。
方法
在儿童（6个月至14岁）和成人（18-41岁）中，在低于1 MAC七氟烷麻醉期间进行脑自动调节试验。采用经颅多普勒超声测量大脑中动脉平均血流速度（V（MCA））。平均动脉压（MAP）升高至较高值：高于基线20%或（i）小于9年80 mm Hg，（ii）9-14年90 mm Hg，（iii）成人100 mm Hg。如果自动调节指数>或=0.4，则认为脑自动调节完好。
结果
有13例2岁以下受试者（第1组）、13例2-5岁受试者（第II组）、14例6-9岁受试者（第III组）、12例10-14岁受试者（第IV组）和12例成人（第V组;对照组）。所有受试者的自动调节指数>或=0.4。I-IV组儿童之间或儿童与成人之间的自动调节指数无差异。
讨论
我们发现在低剂量七氟烷麻醉期间，自动调节能力没有年龄相关的差异。我们报告儿童和成人的自我调节能力没有差异。
INTRODUCTION
Little is known about cerebral autoregulation in children. The aim of this study was to examine cerebral autoregulation in children.
METHODS
Cerebral autoregulation testing was performed during less than 1 MAC sevoflurane anaesthesia in children (from 6 months to 14 yr) and in adults (18-41 yr). Mean middle cerebral artery flow velocities (V(MCA)) were measured using transcranial Doppler ultrasonography. Mean arterial pressure (MAP) was increased to whichever was greater: 20% above baseline or (i) 80 mm Hg for less than 9 yr, (ii) 90 mm Hg for 9-14 yr, and (iii) 100 mm Hg for adults. Cerebral autoregulation was considered intact if the autoregulatory index was > or =0.4.
RESULTS
There were 13 subjects less than 2 yr old (Group 1), 13 subjects 2-5 yr (Group II), 14 subjects 6-9 yr (Group III), 12 subjects 10-14 yr (Group IV), and 12 adults (Group V; control group). All subjects had an autoregulatory index > or =0.4. There was no difference in autoregulatory index between children in Groups I-IV or between children and adults.
DISCUSSION
We found no age-related differences in autoregulatory capacity during low-dose sevoflurane anaesthesia. We report no differences in autoregulatory capacity between children and adults.
影响因子：
8.3
作者：
TIECKS, FP;LAM, AM;NEWELL, DW
通讯作者：
NEWELL, DW