Treatment of cyclic vomiting syndrome with co-enzyme Q10 and amitriptyline, a retrospective study.
Treatment of cyclic vomiting syndrome with co-enzyme Q10 and amitriptyline, a retrospective study.
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DOI：
10.1186/1471-2377-10-10
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发表时间：
2010-01-28
期刊：
影响因子：
2.6
通讯作者：
Adams K
中科院分区：
文献类型：
--
作者：
Boles RG;Lovett-Barr MR;Preston A;Li BU;Adams K
周期性呕吐综合征（CVS）是一种相对常见的致残疾病，与偏头痛和线粒体功能障碍有关，其定义为反复出现的典型恶心和呕吐发作。辅酶Q10 （Co-Q）是一种营养补充剂，已证明对儿童和成人偏头痛有效。尽管完全缺乏证明其治疗价值的研究，但它在CVS中的应用越来越多。通过由CVS患者或其父母填写的基于互联网的调查，询问CVS预防的疗效、耐受性和受试者满意度。服用Co-Q的受试者（22名）与服用阿米替林的受试者（162名）进行比较，阿米替林是一般的护理标准。受试者/家长报告的各种发作参数（频率、持续时间、呕吐次数、恶心严重程度）的疗效水平相似。在72%的阿米替林治疗组和68%的Co-Q治疗组中，这四个参数中至少有一个降低了50%。然而，虽然Co-Q没有副作用的报道，阿米替林50%的受试者报告了副作用（P = 5 × 10-7），导致21%的受试者停止治疗（P = 0.007）。受试者/家长认为阿米替林47%的病例和Co-Q 77%的病例获益大于治疗风险（P = 0.008）。我们的数据表明，天然食品补充剂Co-Q在CVS治疗中具有潜在的有效性和耐受性，应该考虑作为CVS预防的一种选择。我们的数据可能对双盲临床试验的设计有帮助。
Cyclic vomiting syndrome (CVS), which is defined by recurrent stereotypical episodes of nausea and vomiting, is a relatively-common disabling condition that is associated with migraine headache and mitochondrial dysfunction. Co-enzyme Q10 (Co-Q) is a nutritional supplement that has demonstrated efficacy in pediatric and adult migraine. It is increasingly used in CVS despite the complete lack of studies to demonstrate its value in treatment Using an Internet-based survey filled out by subjects with CVS or their parents, the efficacy, tolerability and subject satisfaction in CVS prophylaxis were queried. Subjects taking Co-Q (22 subjects) were compared against those taking amitriptyline (162 subjects), which is the general standard-of-care. Subjects/parents reported similar levels of efficacy for a variety of episode parameters (frequency, duration, number of emesis, nausea severity). There was a 50% reduction in at least one of those four parameters in 72% of subjects treated with amitriptyline and 68% of subjects treated Co-Q. However, while no side effects were reported on Co-Q, 50% of subjects on amitriptyline reported side effects (P = 5 × 10-7), resulting in 21% discontinuing treatment (P = 0.007). Subjects/parents considered the benefits to outweigh the risks of treatment in 47% of cases on amitriptyline and 77% of cases on Co-Q (P = 0.008). Our data suggest that the natural food supplement Co-Q is potentially efficacious and tolerable in the treatment of CVS, and should be considered as an option in CVS prophylaxis. Our data would likely be helpful in the design of a double-blind clinical trial.
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168.9
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