Combined serum levels of multiple proteins in tPA-BDNF pathway may aid the diagnosis of five mental disorders.
Combined serum levels of multiple proteins in tPA-BDNF pathway may aid the diagnosis of five mental disorders.
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tPA-BDNF 通路中多种蛋白的联合血清水平可能有助于诊断五种精神疾病
DOI：
10.1038/s41598-017-06832-6
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发表时间：
2017-07-31
影响因子：
4.6
通讯作者：
Yuan Y
中科院分区：
文献类型：
--
作者：
Chen S;Jiang H;Liu Y;Hou Z;Yue Y;Zhang Y;Zhao F;Xu Z;Li Y;Mou X;Li L;Wang T;Zhao J;Han C;Sui Y;Wang M;Yang Z;Lu Y;Zhu Y;Li J;Shen X;Sun F;Chen Q;Chen H;Yuan Y
精神障碍是一种病因不明的严重致残性疾病，仅使用临床病理学标准时通常会误诊。我们的前期工作表明，联合检测组织型纤溶酶原激活物（tPA）-脑源性神经营养因子（BDNF）通路中多种蛋白的血清水平可提高诊断重度抑郁症（MDD）的准确性。本研究检测了偏执型精神分裂症患者血清tPA、纤溶酶原激活物抑制剂-1（派-1）、BDNF、BDNF受体（proBDNF）、原肌球蛋白相关激酶B（Trk B）和神经营养因子受体p75（p75 NTR）的水平（SZ，n = 34）、MDD（n = 30）、双相躁狂（BM，n = 30）、双相抑郁（BD，n = 22）、惊恐障碍（PD，n = 30）和健康对照（HC，n = 30）。我们使用受试者工作特征曲线（ROC曲线）来分析这些蛋白质的诊断潜力。我们发现，与HC相比，SZ、BM和BD的血清tPA和proBDNF较低; SZ和BD的TrkB较低; SZ和BM的p75 NTR较低。ROC分析显示，联合检测tPA、派-1、BDNF、proBDNF、TrkB和p75 NTR对精神障碍的诊断和鉴别诊断的准确性优于任何单一蛋白，提示联合检测tPA-BDNF通路中的多种血清蛋白水平可能成为精神障碍的一个潜在诊断组合。
Mental disorders are severe, disabling conditions with unknown etiology and are commonly misdiagnosed when clinical symptomology criteria are solely used. Our previous work indicated that combination of serum levels of multiple proteins in tissue plasminogen activator (tPA)-brain-derived neurotrophic factor (BDNF) pathway improved accuracy of diagnosis of major depressive disorder (MDD). Here, we measured serum levels of tPA, plasminogen activator inhibitor-1 (PAI-1), BDNF, precursor-BDNF (proBDNF), tropomyosin-related kinase B (TrkB) and neurotrophin receptor p75 (p75NTR) in patients with paranoid schizophrenia (SZ, n = 34), MDD (n = 30), bipolar mania (BM, n = 30), bipolar depression (BD, n = 22), panic disorder (PD, n = 30), and healthy controls (HCs, n = 30) by Enzyme-linked immunosorbent assay kits. We used receiver operating characteristic (ROC) curve to analyze diagnostic potential of these proteins. We found, compared with HCs, that serum tPA and proBDNF were lower in SZ, BM and BD; TrkB was lower in SZ and BD; and p75NTR was declined in SZ and BM. ROC analysis showed that combined serum level of tPA, PAI-1, BDNF, proBDNF, TrkB and p75NTR was better than any single protein in accuracy of diagnosis and differentiation, suggesting that the combination of multiple serum proteins levels in tPA-BDNF pathway may have a potential for a diagnostic panel in mental disorders.
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影响因子：
11
作者：
Green, M. J.;Matheson, S. L.;Carr, V. J.
通讯作者：
Carr, V. J.
影响因子：
15.1
作者：
Haenisch, Frieder;Cooper, Jason D.;Bahn, Sabine
通讯作者：
Bahn, Sabine
影响因子：
5.3
作者：
Bilello, John A.;Thurmond, Linda M.;Papakostas, George I.
通讯作者：
Papakostas, George I.
影响因子：
9.3
作者：
Fernandes BS;Molendijk ML;Köhler CA;Soares JC;Leite CM;Machado-Vieira R;Ribeiro TL;Silva JC;Sales PM;Quevedo J;Oertel-Knöchel V;Vieta E;González-Pinto A;Berk M;Carvalho AF
通讯作者：
Carvalho AF
影响因子：
1.4
作者：
Kheirouri, Sorayya;Noorazar, Seyed Gholamreza;Dana-Alamdari, Leyli
通讯作者：
Dana-Alamdari, Leyli