Clostridium difficile pilot study: effects of probiotic supplementation on the incidence of C. difficile diarrhoea.
Clostridium difficile pilot study: effects of probiotic supplementation on the incidence of C. difficile diarrhoea.
复制标题
艰难梭菌试点研究：补充益生菌对艰难梭菌腹泻发病率的影响。
DOI：
--
复制
发表时间：
2004
影响因子：
3.1
通讯作者：
J. Hunter
中科院分区：
文献类型：
--
作者：
S. Plummer;M. Weaver;Janine C. Harris;Phillipa Dee;J. Hunter
难辨梭状芽胞杆菌结肠感染导致伪膜性结肠炎是抗生素治疗的常见并发症，尤其是老年患者。有研究表明，非致病性益生菌可以预防艰难梭菌感染的发生和复发。这项双盲、安慰剂对照研究考察了益生菌给药在接受抗生素治疗的老年患者中预防艰难梭菌相关性腹泻(CDAD)的作用。连续接受抗生素治疗的患者(150人)被随机分为两组，一组接受同时含有乳杆菌和双歧杆菌的益生菌，另一组接受为期20天的安慰剂治疗。入院时记录大便习惯并采集粪便样本。试验中在抗生素处方后72小时内服用益生菌或安慰剂，并在住院期间或出院后出现腹泻的情况下采集第二份粪便样本。在随机分组的患者中，138人完成了研究，69人联合使用益生菌和抗生素，69人单独使用抗生素。根据腹泻的发展情况，益生菌组艰难梭菌相关毒素阳性样本的发生率为2.9%，而安慰剂对照组为7.25%。当检测了所有患者的样本时(而不仅仅是那些出现腹泻的患者)，46%的益生菌患者的毒素呈阳性，而安慰剂组的这一比例为78%。
Colonic infection with Clostridium difficile, leading to pseudomembranous colitis, is a common complication of antibiotic therapy, especially in elderly patients. It has been suggested that non-pathogenic probiotic bacteria might prevent the development and recurrence of C. difficile infection. This double-blind, placebo-controlled study examines the role of probiotic administration in the prevention of C. difficile-associated diarrhoea (CDAD) in elderly patients receiving antibiotic therapy. Consecutive patients (150) receiving antibiotic therapy were randomised to receive either a probiotic containing both Lactobacillus and Bifidobacterium or placebo for 20 days. Upon admission to hospital, bowel habit was recorded and a faecal sample taken. Trial probiotic or placebo was taken within 72 h of prescription of antibiotics, and a second stool sample was taken in the event of development of diarrhoea during hospitalisation or after discharge. Of the randomised patients, 138 completed the study, 69 with probiotics in conjunction with antibiotics and 69 with antibiotics alone. On the basis of development of diarrhoea, the incidence of samples positive for C. difficile-associated toxins was 2.9% in the probiotic group compared with 7.25% in the placebo-control group. When samples from all patients were tested (rather than just those developing diarrhoea) 46% of probiotic patients were toxin-positive compared with 78% of the placebo group.
伪膜性结肠炎：并不总是由艰难梭菌引起。
影响因子：
0.8
作者：
Tang,DerekM;Urrunaga,NathalieH;DeGroot,Hannah;vonRosenvinge,ErikC;Xie,Guofeng;Ghazi,LeylaJ
通讯作者：
Ghazi,LeylaJ