Therapeutic Effects of Human Umbilical Cord-Derived Mesenchymal Stem Cells in Acute Lung Injury Mice.
Therapeutic Effects of Human Umbilical Cord-Derived Mesenchymal Stem Cells in Acute Lung Injury Mice.
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人脐带间充质干细胞对急性肺损伤小鼠的治疗作用
DOI：
10.1038/srep39889
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发表时间：
2017-01-04
影响因子：
4.6
通讯作者：
Zou L
中科院分区：
文献类型：
--
作者：
Zhu H;Xiong Y;Xia Y;Zhang R;Tian D;Wang T;Dai J;Wang L;Yao H;Jiang H;Yang K;Liu E;Shi Y;Fu Z;Gao L;Zou L
The incidence and mortality of acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) are still very high, but stem cells show some promise for its treatment. Here we found that intratracheal administration of human umbilical cord-mesenchymal stem cells (UC-MSCs) significantly improved survival and attenuated the lung inflammation in lipopolysaccharide (LPS)-induced ALI mice. We also used the proteins-chip and bioinformatics to analyze interactions between UC-MSCs treatment and immune-response alternations of ALI mice. Then we demonstrated that UC-MSCs could inhibit the inflammatory response of mouse macrophage in ALI mice, as well as enhance its IL-10 expression. We provide data to support the concept that the therapeutic capacity of UC-MSCs for ALI was primarily through paracrine secretion, particularly of prostaglandin-E2 (PGE2). Furthermore, we showed that UC-MSCs might secrete a panel of factors including GM-CSF, IL-6 and IL-13 to ameliorate ALI. Our study suggested that UC-MSCs could protect LPS-induced ALI model by immune regulation and paracrine factors, indicating that UC-MSCs should be a promising strategy for ALI/ARDS.
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影响因子：
82.9
作者：
通讯作者：
--
影响因子：
12.4
作者：
Francois, Moira;Romieu-Mourez, Raphaelle;Galipeau, Jacques
通讯作者：
Galipeau, Jacques
影响因子：
4
作者：
Antunes, Mariana A.;Laffey, John G.;Rocco, Patricia R. M.
通讯作者：
Rocco, Patricia R. M.
DOI：
10.4049/jimmunol.1402513
发表时间：
2015-02-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Han S;Mallampalli RK
通讯作者：
Mallampalli RK
影响因子：
4.3
作者：
Hoegl, Sandra;Boost, Kim A.;Hofstetter, Christian
通讯作者：
Hofstetter, Christian