Quantitative (177)Lu SPECT (QSPECT) imaging using a commercially available SPECT/CT system.
Quantitative (177)Lu SPECT (QSPECT) imaging using a commercially available SPECT/CT system.
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DOI：
10.1102/1470-7330.2011.0012
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发表时间：
2011-06-15
期刊：
影响因子：
--
通讯作者：
Hicks RJ
中科院分区：
文献类型：
--
作者：
Beauregard JM;Hofman MS;Pereira JM;Eu P;Hicks RJ
目的：单光子发射计算机断层扫描（SPECT）和计算机断层扫描（CT）的结合，将迭代重建算法与衰减和散射校正相结合，应有助于准确的非侵入性定量成像。定量 SPECT (QSPECT) 可以提高诊断能力，并且可用于包括剂量测定评估在内的许多应用。使用 177Lu，我们开发了一种使用市售 SPECT/CT 系统的 QSPECT 方法。方法：使用多个连续能量窗口以及共同配准的 CT 采集 177Lu 源 (89-12,400 MBq) 的串行 SPECT，并使用具有衰减和散射校正的迭代算法进行重建。相机灵敏度（基于重建的 SPECT 计数率）和死区时间（基于宽能谱计数率）通过非线性曲线拟合来解决。利用这些参数，SPECT 数据集可以转换为 QSPECT 数据集，允许以贝克勒尔每立方厘米或标准化摄取值 (SUV) 为单位进行定量。验证 QSPECT/CT 研究在 177Lu 圆柱形模型（7 项研究）和 5 名接受治疗剂量[177Lu]奥曲酯的患者（6 项研究）上进行。结果：QSPECT灵敏度为1.08 × 10−5 ± 0.02 × 10−5 s−1 Bq−1。瘫痪死区时间常数为 0.78±0.03μs。在体模和患者中，QSPECT 测得的总活性与校准活性的偏差分别为 5.6±1.9% 和 2.6±1.8%。在患者研究中观察到死时间计数损失高达 11.7%。结论：QSPECT 在我们的模型模型和[177Lu]奥曲酯治疗后的临床实践中都具有很高的准确性。这有可能产生比平面成像更准确的剂量测定估计，并促进治疗反应评估。用其他放射性核素验证这种方法可以为许多其他研究和临床应用开辟道路。
Purpose: The combination of single photon emission computed tomography (SPECT) and computer tomography (CT) that incorporates iterative reconstruction algorithms with attenuation and scatter correction should facilitate accurate non-invasive quantitative imaging. Quantitative SPECT (QSPECT) may improve diagnostic ability and could be useful for many applications including dosimetry assessment. Using 177Lu, we developed a QSPECT method using a commercially available SPECT/CT system. Methods: Serial SPECT of 177Lu sources (89–12,400 MBq) were acquired with multiple contiguous energy windows along with a co-registered CT, and were reconstructed using an iterative algorithm with attenuation and scatter correction. Camera sensitivity (based on reconstructed SPECT count rate) and dead-time (based on wide-energy spectrum count rate) were resolved by non-linear curve fit. Utilizing these parameters, a SPECT dataset can be converted to a QSPECT dataset allowing quantitation in Becquerels per cubic centimetre or standardized uptake value (SUV). Validation QSPECT/CT studies were performed on a 177Lu cylindrical phantom (7 studies) and on 5 patients (6 studies) who were administered a therapeutic dose of [177Lu]octreotate. Results: The QSPECT sensitivity was 1.08 × 10−5 ± 0.02 × 10−5 s−1 Bq−1. The paralyzing dead-time constant was 0.78 ± 0.03 µs. The measured total activity with QSPECT deviated from the calibrated activity by 5.6 ± 1.9% and 2.6 ± 1.8%, respectively, in phantom and patients. Dead-time count loss up to 11.7% was observed in patient studies. Conclusion: QSPECT has high accuracy both in our phantom model and in clinical practice following [177Lu]octreotate therapy. This has the potential to yield more accurate dosimetry estimates than planar imaging and facilitate therapeutic response assessment. Validating this method with other radionuclides could open the way for many other research and clinical applications.
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影响因子：
9.3
作者：
Beauregard, Jean-Mathieu;Croteau, Etienne;Benard, Francois
通讯作者：
Benard, Francois
影响因子：
1.3
作者：
HOFFMAN, EJ;HUANG, SC;PHELPS, ME
通讯作者：
PHELPS, ME
影响因子：
3.5
作者：
Delpon, G;Ferrer, L;Bardiès, M
通讯作者：
Bardiès, M
影响因子：
6.2
作者：
Garkavij, Michael;Nickel, Mattias;Tennvall, Jan
通讯作者：
Tennvall, Jan
影响因子：
2.2
作者：
Pereira, J. M.;Stabin, M. G.;Forrester, J. W.
通讯作者：
Forrester, J. W.