Relation of DDT residues to plasma retinol, α-tocopherol, and β-carotene during pregnancy and malaria infection: A case–control study in Karen women in northern Thailand
Relation of DDT residues to plasma retinol, α-tocopherol, and β-carotene during pregnancy and malaria infection: A case–control study in Karen women in northern Thailand
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妊娠和疟疾感染期间 DDT 残留与血浆视黄醇、α-生育酚和 β-胡萝卜素的关系：泰国北部克伦族妇女的病例对照研究
DOI：
10.1016/j.scitotenv.2005.06.032
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发表时间：
2006
影响因子：
9.8
通讯作者：
F. Nosten
中科院分区：
文献类型：
--
作者：
W. Stuetz;R. McGready;Thein Cho;T. Prapamontol;H. Biesalski;K. Stȩpniewska;F. Nosten
疟疾流行区的居民可能同时接触滴滴涕和疟疾感染。滴滴涕可能损害维生素的状况，而维生素与疟疾的免疫和病理生理有关。为探讨可能的相互作用，对疟疾感染孕妇（病例，n=50）和年龄匹配的无疟疾对照（n=58）血浆样本中的滴滴涕残留、视黄醇、α-生育酚、β-胡萝卜素和胆固醇进行了测定。在所有样本中都发现了滴滴涕残留物：病例和对照组的滴滴涕总平均水平分别为29.7和32.7纳克/毫升。对照组的p，p′-DDT平均值（sd）高于病例组（13.5 vs. 9.5 ng/ml，p=0.006）。与对照组相比，疟疾感染与较低的平均（sd）血浆视黄醇（0.69 vs. 1.23 μmol/L）和胆固醇（2.62 vs. 3.48 mmol/L）相关（p<0.001）。对照组的平均（sd）血浆α-生育酚（7.65 vs. 15.58 μmol/L）和α-生育酚/胆固醇比值（2.3 vs. 6.7 μmol/L/mmol/L）显著较低（p<0.001）。两组患者血浆β-胡萝卜素的平均值（标准差）均较低（<0.3 μmol/L），但疟疾患者血浆β-胡萝卜素的平均值较高（0.19对0.15 μmol/L）。对照组血浆视黄醇含量与DDT各化合物含量呈极显著正相关（r=0.51，p<0.001），与p，p′-DDT的相关性最强。血浆α-生育酚和β-胡萝卜素似乎不受DDT残留的影响。
Populations living in endemic malaria areas maybe exposed simultaneously to DDT and malaria infection. DDT may impair status of vitamins, which are implicated in the immunity and pathophysiology of malaria. To explore possible interactions, DDT residues, retinol, α-tocopherol, β-carotene and cholesterol were measured in plasma samples of malaria-infected pregnant women (cases, n=50) and age matched malaria-free controls (n=58). DDT residues were found in all samples: mean (sd) total DDT levels of 29.7 and 32.7 ng/ml in cases and controls, respectively. Mean (sd) p,p′-DDT was higher in the controls than the cases (13.5 vs. 9.5 ng/ml, p=0.006). Malaria infection was associated with lower mean (sd) plasma retinol (0.69 vs. 1.23 μmol/L) and cholesterol (2.62 vs. 3.48 mmol/L) compared to controls (p<0.001). Mean (sd) plasma α-tocopherol (7.65 vs. 15.58 μmol/L) and α-tocopherol/cholesterol ratio (2.3 vs. 6.7 μmol/L/mmol/L) were significantly lower among the controls (p<0.001). Mean (sd) plasma β-carotene was low (<0.3 μmol/L) in both groups, but higher among malaria cases (0.19 vs. 0.15 μmol/L). Plasma retinol among the controls showed highly significant positive correlations with individual DDT compounds, particularly with p,p′-DDT (r=0.51, p<0.001). Plasma α-tocopherol and β-carotene seemed not to be affected by DDT residues.
DOI：
10.1080/00039899909602244
发表时间：
1999-03-01
期刊：
ARCHIVES OF ENVIRONMENTAL HEALTH
影响因子：
--
作者：
Longnecker, MP;Klebanoff, MA;Berendes, HW
通讯作者：
Berendes, HW
影响因子：
6.1
作者：
Semba, RD
通讯作者：
Semba, RD
影响因子：
5.6
作者：
Korrick, SA;Chen, CZ;Xu, XP
通讯作者：
Xu, XP