The Battle of RNA Synthesis: Virus versus Host.

The Battle of RNA Synthesis: Virus versus Host.
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DOI:
10.3390/v9100309
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发表时间:
2017-10-21
期刊:
Viruses
影响因子:
--
通讯作者:
Berkhout B
Berkhout B
中科院分区:
其他
文献类型:
--
作者:
Harwig A;Landick R;Berkhout B

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转录控制是基因调控的基础。细胞完全具备完成这一任务的能力,而病毒通常依赖宿主为其转录程序提供工具。在进化和适应的过程中,病毒已经找到了各种各样的方法来优化利用细胞宿主的过程,如转录,以达到自己的利益。正如人们越来越了解细胞在转录调节中使用新生rna一样,最近的发现揭示了病毒如何使用新生rna来促进自身基因表达。在这篇综述中,我们首先概述了病毒使用的两种不同的转录程序,即转录(dna依赖)和RNA依赖的RNA合成。随后,我们使用不同的阶段(起始,延伸,终止)来描述在每个相关阶段背景下对新生rna介导调控的最新见解。
Transcription control is the foundation of gene regulation. Whereas a cell is fully equipped for this task, viruses often depend on the host to supply tools for their transcription program. Over the course of evolution and adaptation, viruses have found diverse ways to optimally exploit cellular host processes such as transcription to their own benefit. Just as cells are increasingly understood to employ nascent RNAs in transcription regulation, recent discoveries are revealing how viruses use nascent RNAs to benefit their own gene expression. In this review, we first outline the two different transcription programs used by viruses, i.e., transcription (DNA-dependent) and RNA-dependent RNA synthesis. Subsequently, we use the distinct stages (initiation, elongation, termination) to describe the latest insights into nascent RNA-mediated regulation in the context of each relevant stage.
流感A病毒表达中使用的核糖体框架发生在序列UCC_UUU_CGU内,并且位于+1方向。
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