The Difference Between High Density Lipoprotein Subfractions and Subspecies: an Evolving Model in Cardiovascular Disease and Diabetes.
The Difference Between High Density Lipoprotein Subfractions and Subspecies: an Evolving Model in Cardiovascular Disease and Diabetes.
复制标题
高密度脂蛋白亚组分和亚种之间的差异：心血管疾病和糖尿病的进化模型。
DOI：
10.1007/s11883-021-00925-4
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发表时间：
2021-03-27
影响因子：
5.8
通讯作者：
Shah AS
中科院分区：
文献类型：
--
作者：
Davidson WS;Cooke AL;Swertfeger DK;Shah AS
高密度脂蛋白（HDL）一词是指在生理上起不同作用的亚粒子的集合。在这里，我们定义了术语“HDL亚种”，并回顾了其分子特征及其与疾病的关系，重点是心血管疾病和糖尿病。高密度脂蛋白家族包含200多种蛋白质和近200种脂质，它们在血浆中分解成不同的颗粒。根据特定的物理化学性质对HDL进行简单的分馏并不能揭示特定颗粒在疾病中的作用。然而，通过针对少量蛋白质或脂质成分，已经描述和表征了少数组成定义的HDL亚种。通过结合靶向颗粒分离技术和大规模人体研究的力量，在了解HDL亚种的功能和对疾病的影响方面正在取得进展。然而，在将这些进展转化为疾病缓解战略之前，还有许多工作要做。
The term high density lipoproteins (HDL) refers to an eclectic collection of subparticles that play diverse roles in physiology. Here, we define the term ‘HDL subspecies’ and review recent work on their molecular characterization and relation to disease, focusing on cardiovascular disease and diabetes. The HDL family contains over 200 proteins and nearly 200 lipids that partition into different particles in plasma. Simple subfractionation of HDL based on a particular physicochemical property has not risen to the challenge of revealing the roles of specific particles in disease. However, by targeting minor protein or lipid components, a handful of compositionally defined HDL subspecies have been described and characterized. By combining targeted particle isolation techniques with the power of large human studies, progress is being made in understanding HDL subspecies functions and implications for disease. However, much work remains before these advancements can be translated into disease mitigation strategies.
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影响因子：
5.8
作者：
Chandra, Alvin;Rohatgi, Anand
通讯作者：
Rohatgi, Anand
影响因子：
2.9
作者：
CASTRO, GR;FIELDING, CJ
通讯作者：
FIELDING, CJ
影响因子：
3.7
作者：
Bausch-Fluck D;Hofmann A;Bock T;Frei AP;Cerciello F;Jacobs A;Moest H;Omasits U;Gundry RL;Yoon C;Schiess R;Schmidt A;Mirkowska P;Härtlová A;Van Eyk JE;Bourquin JP;Aebersold R;Boheler KR;Zandstra P;Wollscheid B
通讯作者：
Wollscheid B
影响因子：
4.4
作者：
Gordon SM;Deng J;Lu LJ;Davidson WS
通讯作者：
Davidson WS
DOI：
10.1161/atvbaha.118.311607
发表时间：
2018-12-01
影响因子：
8.7
作者：
Furtado, Jeremy D.;Yamamoto, Rain;Sacks, Frank M.
通讯作者：
Sacks, Frank M.