EFFECTS OF APPLIED STRESS ON PREFERENTIAL ALIGNMENT OF BIOLOGICAL APATITE IN RABBIT FORELIMB BONES
EFFECTS OF APPLIED STRESS ON PREFERENTIAL ALIGNMENT OF BIOLOGICAL APATITE IN RABBIT FORELIMB BONES
复制标题
施加应力对兔前肢骨中生物磷灰石优先排列的影响
DOI：
10.3363/prb1992.17.0_77
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发表时间：
2004
期刊：
影响因子：
--
通讯作者：
Y. Tabata
中科院分区：
文献类型：
--
作者：
Takuya Ishimoto;T. Nakano;Y. Umakoshi;Masaya Yamamoto;Y. Tabata
研究了兔前肢骨中应力分布及其变化对生物磷灰石（BAp）密度和取向的影响。分别通过外周定量计算机断层扫描（pQCT）和微束X射线衍射系统分析骨密度（BMD）和BAp对齐。由尺骨和桡骨组成的完整的原始兔前肢骨表现出沿着纵向方向的BAp的c轴的一维优先对齐，但取向的程度强烈依赖于从骨横截面上的中性点的距离。这表明，除了沿长骨沿着的轴向应力外，BAp对线还受到弯曲应力的敏感控制。在尺骨缺损10 mm的兔模型中，尺骨中的BAp对准以及BMD敏感地根据缺损中骨愈合期间的载荷条件而改变。在卸载和重新加载过程中，BAp排列减少和增加，分别。因此，可以得出结论，不仅BMD，而且BAp对齐的变化取决于所施加的应力的基础上的功能适应骨。（2004年7月26日接收; 2004年8月28日接受）
Effects of stress distribution and its change in vivo on density and orientation of biological apatite (BAp) were investigated in rabbit forelimb bones. Bone mineral density (BMD) and BAp alignment were analyzed by a peripheral quantitative computed tomography (pQCT) and a micro-beam X-ray diffraction system, respectively. The intact original rabbit forelimb bone consisting of an ulna and a radius exhibited a one-dimensional preferential alignment of the c-axis of BAp along the longitudinal direction, but the degree of orientation depended strongly on the distance from the neutral point on the bone cross section. This suggests that the BAp alignment is sensitively controlled by the bending stress in addition to the axial stress along the long bone. In the rabbit model with a 10 mm defect on the ulna, the BAp alignment as well as BMD in the ulna sensitively changed depending on the loading condition during the bone healing in the defect. The BAp alignment decreased and increased during unloading and reloading, respectively. Therefore, it is concluded that not only BMD but also BAp alignment changes depending on the applied stress on the basis of the functional adaptation in bones. (Received July 26, 2004; Accepted August 28, 2004)
影响因子：
2.4
作者：
Coleman,JohnC;Hart,RichardT;Owan,Ichiro;Tankano,Yuichi;Burr,DavidB
通讯作者：
Burr,DavidB
影响因子：
4.1
作者：
LANDIS, WJ
通讯作者：
LANDIS, WJ