Effect of piracetam on the cognitive performance of patients undergoing coronary bypass surgery: A meta-analysis.
Effect of piracetam on the cognitive performance of patients undergoing coronary bypass surgery: A meta-analysis.
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DOI：
10.3892/etm.2013.1425
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发表时间：
2014-02
影响因子：
2.7
通讯作者：
Zhang S
中科院分区：
文献类型：
--
作者：
Fang Y;Qiu Z;Hu W;Yang J;Yi X;Huang L;Zhang S
在许多冠状动脉旁路手术后的患者中观察到认知障碍，而吡拉西坦是一种通过直接增强认知过程来调节大脑功能的促性化合物。本研究旨在评价吡拉西坦对冠状动脉搭桥术患者认知功能的保护作用。通过检索Medline、EMBASE、PubMed和Cochrane图书馆，确定截至2013年6月的相关研究，并对检索到的研究的相关文献进行综述。数据是根据预先定义的标准从研究中选取的。荟萃分析包括两个随机对照试验，涉及184名患者，包括综合征-库尔茨检验(SKT)。荟萃分析的结果显示，在治疗后，在对吡拉西坦患者进行的5项SKT分测试中观察到的与基线的变化表明，与安慰剂组的患者相比，这一变化具有显著的优势。分测验包括即时图片物体回忆，加权平均差=0.91，95%可信区间0.51~1.31，P&0.00001；延迟图片物体回忆，加权平均差=0.74，95%CI 0.19~1.28，P=0.008；延迟图片再认，加权平均差=0.82，95%CI 0.31~1.31，P=0.001；字母干扰，−=3.46，95%CI为5.69，−为1.23，P=0.002。这些结果表明，吡拉西坦可能有效地改善了接受冠状动脉旁路手术的患者的短期认知能力。需要高质量、控制良好、时间更长的随机试验来证实这一结果。
Cognitive impairments are observed in numerous patients following coronary bypass surgery, and piracetam are nootropic compounds that modulate cerebral functions by directly enhancing cognitive processes. The present meta-analysis was conducted to evaluate the protective effect of piracetam on the cognitive performance of patients undergoing coronary bypass surgery. The relevant studies were identified by searching Medline, EMBASE, PubMed and the Cochrane Library up to June 2013 and the pertinent bibliographies from the retrieved studies were reviewed. Data were selected from the studies according to predefined criteria. The meta-analysis included two randomized control trials involving 184 patients and including the Syndrom-Kurz test (SKT). Findings of the meta-analysis showed that following treatment the change from baseline observed in five SKT subtest scores, conducted with piracetam patients, indicated a significant advantage over those patients that were in the placebo group. The subtests included immediate pictured object recall, weighted mean difference (WMD)=0.91, 95% confidence interval (CI) 0.51–1.31, P<0.00001; delayed pictured object recall, WMD=0.74, 95% CI 0.19–1.28, P=0.008; delayed picture recognition, WMD=0.82, 95% CI 0.31–1.31, P=0.001; immediate word recall, WMD=0.87, 95% CI 0.47–1.28, P<0.0001; and letter interference, WMD=3.46, 95% CI −5.69 to −1.23, P=0.002. These results indicated that piracetam may have been effective in improving the short-term cognitive performance of patients undergoing coronary bypass surgery. High quality, well-controlled and longer randomized trials are required to corroborate this result.
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影响因子：
8.3
作者：
Arrowsmith, JE;Harrison, MJG;Pugsley, WB
通讯作者：
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