Decreased P27 protein expression is correlated with the progression and poor prognosis of nasopharyngeal carcinoma.
Decreased P27 protein expression is correlated with the progression and poor prognosis of nasopharyngeal carcinoma.
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P27蛋白表达降低与鼻咽癌的进展和不良预后相关
DOI：
10.1186/1746-1596-8-212
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发表时间：
2013-12-20
影响因子：
2.6
通讯作者：
Liu Z
中科院分区：
文献类型：
--
作者：
Jiang Q;Yang H;Cheng C;Xiong H;Liu S;Long J;Zhang Y;Fang W;Liu Z
背景目的探讨细胞周期蛋白依赖性激酶抑制剂1B（p27）表达与鼻咽癌（NPC）临床病理特征（包括患者预后）的相关性。方法采用实时荧光定量PCR和免疫组化检测鼻咽癌和鼻咽组织中p27 mRNA和蛋白的表达。分析鼻咽癌患者p27表达水平与临床特征及预后的关系。结果鼻咽癌组织中p27 mRNA表达水平显着低于鼻咽组织(P = 0.0006)。免疫组织化学染色在鼻咽癌和恶性上皮细胞的细胞核和细胞质中发现特异性p27蛋白染色，但与正常上皮样本相比，鼻咽癌样本中观察到表达降低（P = 0.002）。此外，低水平的p27蛋白与鼻咽癌患者的T分类状态（p = 0.002）和临床分期（p = 0.019）呈负相关。 p27 表达较低的患者的总生存时间明显短于 p27 高表达的患者。多变量分析表明p27表达水平并不是鼻咽癌生存的独立预后指标（p = 0.682）。结论低水平的p27表达是鼻咽癌患者潜在的不利预后因素。虚拟幻灯片本文的虚拟幻灯片可以在这里找到： http://www.diagnosticpathology.diagnomx.eu/vs/1915282782109343。
BackgroundTo determine the correlation of cyclin-dependent kinase inhibitor 1B (p27) expression with clinicopathologic features in nasopharyngeal carcinoma (NPC), including patient prognosis.MethodsReal-time PCR and immunohistochemistry were used to examine the mRNA and protein expressions of p27 in NPC and nasopharyngeal tissues. The relationship of p27 expression levels with clinical features and prognosis of NPC patients was analyzed.ResultsThe expression level of p27 mRNA was markedly lower in NPC tissues than that in the nasopharyngeal tissues (P = 0.0006). Specific p27 protein staining by immunohistochemistry was found in the nuclei and cytoplasm of nasopharyngeal and malignant epithelial cells but decreased expression was observed in NPC samples compared to normal epithelium samples (P = 0.002). In addition, low levels of p27 protein were inversely correlated with the status of T classification (p = 0.002) and clinical stage (p = 0.019) of NPC patients. Patients with lower p27 expression had a significantly shorter overall survival time than did patients with high p27 expression. Multivariate analysis suggested that the level of p27 expression was not an independent prognostic indicator (p = 0.682) for NPC survival.ConclusionLow level of p27 expression is a potential unfavorable prognostic factor for patients with NPC.Virtual slidesThe virtual slide (s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1915282782109343 .
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影响因子：
9
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影响因子：
6.4
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影响因子：
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作者：
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通讯作者：
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影响因子：
11.2
作者：
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