The Association of Obesity and Cardiometabolic Traits With Incident HFpEF and HFrEF.
The Association of Obesity and Cardiometabolic Traits With Incident HFpEF and HFrEF.
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DOI：
10.1016/j.jchf.2018.05.018
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发表时间：
2018-08
期刊：
影响因子：
--
通讯作者：
Ho JE
中科院分区：
文献类型：
--
作者：
Savji N;Meijers WC;Bartz TM;Bhambhani V;Cushman M;Nayor M;Kizer JR;Sarma A;Blaha MJ;Gansevoort RT;Gardin JM;Hillege HL;Ji F;Kop WJ;Lau ES;Lee DS;Sadreyev R;van Gilst WH;Wang TJ;Zanni MV;Vasan RS;Allen NB;Psaty BM;van der Harst P;Levy D;Larson M;Shah SJ;de Boer RA;Gottdiener JS;Ho JE
我们评估了肥胖和心脏代谢特征与射血分数保留和减少的心力衰竭事件之间的关系(HFpEF与HFrEF)。鉴于已知的心力衰竭亚型的性别差异，我们分别检查了男性和女性。最近的研究表明，肥胖比HFrEF具有更大的HFpEF风险。相关代谢性状对HFpEF的贡献不太清楚。我们研究了来自4个社区队列的22,681名参与者的高场高压与高场高压事件(EF>；vs≤50%)。我们使用COX模型评估了体重指数(BMI)和心脏代谢特征与心力衰竭亚型的关系。平均年龄60±13岁，女性占53%。在12年的中位随访期中，628人发生了HFPEF，835人发生了HFrEF。BMI越大，患HFpEF的风险越高(HFpEF：体重指数每1个标准差(SD)增加HR 1.34；95%CI 1.24~1.45 vs HFrEF：HR 1.18；95%CI 1.10~1.27)。同样，胰岛素抵抗(HOMA-IR)与HFpEF相关(HR为1.20/1SD，95%CI为1.05-1.37)，而与HFrEF无关(HR为0.99，95%CI为0.88-1.11；HFpEF与HFrEF差异为P<；0.05)。我们发现BMI与HFpEF和HFrEF之间的差异在女性中更明显(P=0.01)，而男性(P=0.34)。肥胖和相关的心脏代谢特征，包括胰岛素抵抗，与HFrEF相比，与未来的HFpEF风险更密切相关。HFpEF与肥胖的不同风险在女性中似乎特别明显，这可能是HF亚型性别差异的基础。
We evaluated the associations of obesity and cardiometabolic traits with incident heart failure with preserved vs reduced ejection fraction (HFpEF vs HFrEF). Given known sex differences in HF subtype, we examined men and women separately. Recent studies suggest that obesity confers greater risk of HFpEF vs HFrEF. Contributions of associated metabolic traits to HFpEF are less clear. We studied 22,681 participants from 4 community-based cohorts followed for incident HFpEF vs HFrEF (EF> vs ≤50%). We evaluated the association of body mass index (BMI) and cardiometabolic traits with incident HF subtype using Cox models. The mean age was 60±13 years, 53% were women. Over a median follow-up of 12 years, 628 developed incident HFpEF and 835 HFrEF. Greater BMI portended higher risk of HFpEF compared with HFrEF (HFpEF: HR 1.34 per 1 standard deviation (SD) increase in BMI; 95% CI 1.24-1.45 vs HFrEF: HR 1.18; 95% CI 1.10-1.27). Similarly, insulin resistance (HOMA- IR) was associated with HFpEF (HR 1.20 per 1 SD, 95% CI 1.05-1.37), but not HFrEF (HR 0.99, 95% CI 0.88–1.11; P<0.05 for difference HFpEF vs HFrEF). We found that the differential association of BMI with HFpEF vs HFrEF was more pronounced among women (P for difference HFpEF vs HFrEF=0.01) when compared with men (P=0.34). Obesity and related cardiometabolic traits including insulin resistance are more strongly associated with risk of future HFpEF vs HFrEF. The differential risk of HFpEF with obesity appears particularly pronounced among women and may underlie sex differences in HF subtypes.
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DOI：
10.1016/j.jchf.2013.07.006
发表时间：
2013-12
期刊：
JACC. Heart failure
影响因子：
--
作者：
Vardeny O;Gupta DK;Claggett B;Burke S;Shah A;Loehr L;Rasmussen-Torvik L;Selvin E;Chang PP;Aguilar D;Solomon SD
通讯作者：
Solomon SD
影响因子：
37.8
作者：
Jelic S;Lederer DJ;Adams T;Padeletti M;Colombo PC;Factor PH;Le Jemtel TH
通讯作者：
Le Jemtel TH
影响因子：
37.8
作者：
Lieb W;Xanthakis V;Sullivan LM;Aragam J;Pencina MJ;Larson MG;Benjamin EJ;Vasan RS
通讯作者：
Vasan RS
影响因子：
24
作者：
Russo, Cesare;Jin, Zhezhen;Di Tullio, Marco R.
通讯作者：
Di Tullio, Marco R.
通过保留和减少的射血分数来预测心力衰竭：心力衰竭亚型的国际合作。
DOI：
10.1161/circheartfailure.115.003116
发表时间：
2016-06
期刊：
Circulation. Heart failure
影响因子：
--
作者：
Ho JE;Enserro D;Brouwers FP;Kizer JR;Shah SJ;Psaty BM;Bartz TM;Santhanakrishnan R;Lee DS;Chan C;Liu K;Blaha MJ;Hillege HL;van der Harst P;van Gilst WH;Kop WJ;Gansevoort RT;Vasan RS;Gardin JM;Levy D;Gottdiener JS;de Boer RA;Larson MG
通讯作者：
Larson MG