CD8+ lymphocyte infiltration is an independent favorable prognostic indicator in basal-like breast cancer.
CD8+ lymphocyte infiltration is an independent favorable prognostic indicator in basal-like breast cancer.
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DOI：
10.1186/bcr3148
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发表时间：
2012-03-15
期刊：
影响因子：
--
通讯作者：
Nielsen TO
中科院分区：
文献类型：
--
作者：
Liu S;Lachapelle J;Leung S;Gao D;Foulkes WD;Nielsen TO
肿瘤浸润淋巴细胞可能表明对癌症发展的免疫反应，但其在乳腺癌中的意义仍有争议。我们进行了这项研究，以评估CD 8+（细胞毒性T）淋巴细胞浸润在一个大型队列的浸润性早期乳腺癌，并评估其预后的影响，在不同的乳腺癌内在亚型。对来自3992名乳腺癌患者的组织微阵列进行CD 8染色的免疫组化。当与肿瘤细胞直接接触时，CD 8+肿瘤浸润淋巴细胞计数为肿瘤内淋巴细胞，并且在相邻位置计数为基质淋巴细胞。应用Kaplan-Meier函数和考克斯比例风险回归模型分析肿瘤浸润淋巴细胞与乳腺癌特异性生存率之间的关系。在3403例获得免疫组化结果的病例中，CD 8+肿瘤浸润淋巴细胞在32%的病例中被鉴定为瘤内模式，在61%的病例中被鉴定为间质模式。在整个队列中，肿瘤内浸润淋巴细胞的存在与年轻、高级别、雌激素受体阴性、人表皮生长因子受体2阳性和核心基底固有亚型显著相关，并与上级乳腺癌特异性生存相关。多因素分析显示，CD 8+肿瘤浸润淋巴细胞仅在核心基础内源性亚组中具有显著的预后作用（危险比，HR = 0.35，95%CI = 0.23-0.54）。在那些缺乏基础标志物表达的三阴性乳腺癌中（HR = 0.99，95%CI = 0.48-2.04），也不存在与生存期改善的相关性。CD 8+肿瘤浸润淋巴细胞是基底细胞样乳腺癌患者生存率较好的独立预后因素，但在非基底细胞三阴性乳腺癌或其他内在分子亚型中则不然。
Tumor infiltrating lymphocytes may indicate an immune response to cancer development, but their significance remains controversial in breast cancer. We conducted this study to assess CD8+ (cytotoxic T) lymphocyte infiltration in a large cohort of invasive early stage breast cancers, and to evaluate its prognostic effect in different breast cancer intrinsic subtypes. Immunohistochemistry for CD8 staining was performed on tissue microarrays from 3992 breast cancer patients. CD8+ tumor infiltrating lymphocytes were counted as intratumoral when in direct contact with tumor cells, and as stromal in adjacent locations. Kaplan-Meier functions and Cox proportional hazards regression models were applied to examine the associations between tumor infiltrating lymphocytes and breast cancer specific survival. Among 3403 cases for which immunohistochemical results were obtained, CD8+ tumor infiltrating lymphocytes were identified in an intratumoral pattern in 32% and stromal pattern in 61% of the cases. In the whole cohort, the presence of intratumoral tumor-infiltrating lymphocytes was significantly correlated with young age, high grade, estrogen receptor negativity, human epidermal growth factor receptor-2 positivity and core basal intrinsic subtype, and was associated with superior breast cancer specific survival. Multivariate analysis indicated that the favorable prognostic effect of CD8+ tumor infiltrating lymphocytes was significant only in the core basal intrinsic subgroup (Hazard ratio, HR = 0.35, 95% CI = 0.23-0.54). No association with improved survival was present in those triple negative breast cancers that lack expression of basal markers (HR = 0.99, 95% CI = 0.48-2.04) nor in the other intrinsic subtypes. CD8+ tumor infiltrating lymphocytes are an independent prognostic factor associated with better patient survival in basal-like breast cancer, but not in non-basal triple negative breast cancers nor in other intrinsic molecular subtypes.
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乳腺癌的分子分析：临床意义。
影响因子：
8.8
作者：
Cleator, S;Ashworth, A
通讯作者：
Ashworth, A
DOI：
10.1073/pnas.0912708107
发表时间：
2010-04-13
影响因子：
11.1
作者：
Gatza, Michael L.;Lucas, Joseph E.;Nevins, Joseph R.
通讯作者：
Nevins, Joseph R.
影响因子：
3.7
作者：
Camp, BJ;Dyhrman, ST;Barth, RJ
通讯作者：
Barth, RJ
影响因子：
8.4
作者：
Edén, P;Ritz, C;Peterson, C
通讯作者：
Peterson, C
影响因子：
50.3
作者：
DeNardo DG;Barreto JB;Andreu P;Vasquez L;Tawfik D;Kolhatkar N;Coussens LM
通讯作者：
Coussens LM