Ontogeny of small RNA in the regulation of mammalian brain development.
Ontogeny of small RNA in the regulation of mammalian brain development.
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DOI：
10.1186/1471-2164-15-777
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发表时间：
2014-09-09
期刊：
影响因子：
4.4
通讯作者：
Cairns MJ
中科院分区：
文献类型：
--
作者：
Hollins SL;Goldie BJ;Carroll AP;Mason EA;Walker FR;Eyles DW;Cairns MJ
microRNA（miRNAs）在几乎所有已知的生物过程中（包括中枢神经系统的发育）在协调信使RNA（mRNA）的转录和稳定性方面发挥关键作用。尽管我们对它们的参与有着广泛的了解，但我们仍然对miRNA如何对大脑发育的严格区域和时间调节做出贡献有着非常稀疏的了解。因此，在目前的研究中，我们使用全基因组微阵列策略研究了从神经管闭合后到出生的发育中大鼠端脑和中脑中miRNA的贡献。我们确定了端脑和中脑中miRNA及其靶基因的时间上不同的表达模式。我们证明了直接miRNA靶向参与神经元迁移，分化和成熟的几个基因。我们的研究结果表明，miRNA对神经结构的发育具有重要意义，并支持重要的机制，如果被破坏，可能会导致或驱动神经发育障碍。本文的在线版本（doi：10.1186/1471-2164-15-777）包含补充材料，可供授权用户使用。
MicroRNAs (miRNAs) play a pivotal role in coordinating messenger RNA (mRNA) transcription and stability in almost all known biological processes, including the development of the central nervous system. Despite our broad understanding of their involvement, we still have a very sparse understanding of specifically how miRNA contribute to the strict regional and temporal regulation of brain development. Accordingly, in the current study we have examined the contribution of miRNA in the developing rat telencephalon and mesencephalon from just after neural tube closure till birth using a genome-wide microarray strategy. We identified temporally distinct expression patterns in both the telencephalon and mesencephalon for both miRNAs and their target genes. We demonstrate direct miRNA targeting of several genes involved with the migration, differentiation and maturation of neurons. Our findings suggest that miRNA have significant implications for the development of neural structure and support important mechanisms that if disrupted, may contribute to or drive neurodevelopmental disorders. The online version of this article (doi:10.1186/1471-2164-15-777) contains supplementary material, which is available to authorized users.
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影响因子：
3.3
作者：
Figueroa, Angelica;Kotani, Hirokazu;Fujita, Yasuyuki
通讯作者：
Fujita, Yasuyuki
影响因子：
6.8
作者：
Eyles, D.;Feldon, J.;Meyer, U.
通讯作者：
Meyer, U.
影响因子：
3.5
作者：
Gaughwin, Philip Michael;Ciesla, Maciej;Bjorkqvist, Maria
通讯作者：
Bjorkqvist, Maria
影响因子：
56.9
作者：
Farh, KKH;Grimson, A;Bartel, DP
通讯作者：
Bartel, DP
DOI：
10.1523/jneurosci.3883-11.2011
发表时间：
2011-10-12
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Geekiyanage H;Chan C
通讯作者：
Chan C