Shared brain vulnerabilities open the way for nonsubstance addictions: carving addiction at a new joint?
Shared brain vulnerabilities open the way for nonsubstance addictions: carving addiction at a new joint?
复制标题
DOI：
10.1111/j.1749-6632.2009.05420.x
复制
发表时间：
2010-02
影响因子：
5.2
通讯作者：
Childress AR
中科院分区：
文献类型：
--
作者：
Frascella J;Potenza MN;Brown LL;Childress AR
半个多世纪以来，自从正式诊断学开始以来，我们的精神病理学家将对物质(如酒精、可卡因、海洛因、尼古丁)的强迫性追求与非物质(如赌博、食物、性)的奖励区分开来。新出现的大脑、行为和基因发现挑战了这一诊断边界，指出了病理性地追求物质和非物质奖励的共同弱点。因此，第五版《精神疾病诊断和统计手册》(DSM-V)第五次修订工作组正在考虑是否应重新划定成瘾的病因学界限，将赌博等非物质障碍包括在内。这篇综述讨论了来自问题赌博、肥胖和依恋状态(浪漫迷恋、性吸引、母性纽带)的神经生物学数据如何帮助我们在一个新的关节上刻画成瘾的任务。诊断重算可能会对成瘾研究产生积极影响，刺激发现对物质和非物质成瘾都有好处的“交叉”药物疗法。
For more than half a century, since the beginning of formal diagnostics, our psychiatric nosology has compartmentalized the compulsive pursuit of substance (e.g., alcohol, cocaine, heroin, nicotine) from nonsubstance (e.g., gambling, food, sex) rewards. Emerging brain, behavioral, and genetic findings challenge this diagnostic boundary, pointing to shared vulnerabilities underlying the pathological pursuit of substance and nonsubstance rewards. Working groups for the fifth revision of theDiagnostic and Statistical Manual of Mental Disorders, fifth edition (DSM‐V), are thus considering whether the nosologic boundaries of addiction should be redrawn to include nonsubstance disorders, such as gambling. This review discusses how neurobiological data from problem gambling, obesity, and “normal” states of attachment (romantic infatuation, sexual attraction, maternal bonds) may help us in the task of carving addictions “at a new joint.” Diagnostic recarving may have a positive effect on addiction research, stimulating discovery of “crossover” pharmacotherapies with benefit for both substance and nonsubstance addictions.
登录
查看更多内容
影响因子：
5.3
作者：
Bradberry, CW
通讯作者：
Bradberry, CW
影响因子：
1.1
作者：
Brewer, Judson A.;Grant, Jon E.;Potenza, Marc N.
通讯作者：
Potenza, Marc N.
影响因子：
2.8
作者：
Ameisen, O
通讯作者：
Ameisen, O
影响因子：
2.8
作者：
Brebner, K;Childress, AR;Roberts, DCS
通讯作者：
Roberts, DCS
影响因子：
14.5
作者：
Arnow, BA;Desmond, JE;Atlas, SW
通讯作者：
Atlas, SW