Constitutive NF-kappaB activity regulates the expression of VEGF and IL-8 and tumor angiogenesis of human glioblastoma.
Constitutive NF-kappaB activity regulates the expression of VEGF and IL-8 and tumor angiogenesis of human glioblastoma.
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组成型 NF-κB 活性调节 VEGF 和 IL-8 的表达以及人胶质母细胞瘤的肿瘤血管生成。
DOI：
10.3892/or-00000690
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发表时间：
2010-03
期刊：
影响因子：
--
通讯作者：
夏之柏
中科院分区：
文献类型：
--
作者：
夏之柏
血管生成是胶质母细胞瘤的一个重要病理特征，胶质母细胞瘤是成人中最常见和最致命的原发性脑肿瘤。血管生成的程度已被证明是负相关的患者生存。然而，导致胶质母细胞瘤血管生成的分子变化仍然知之甚少。在本研究中，我们发现成胶质细胞瘤中核因子（NF）-κ B活化与血管生成之间存在直接相关性。阻断NF-κ B信号传导可显著抑制裸鼠胶质母细胞瘤生长和血管生成。这些作用与体外和体内多种血管生成分子（包括血管内皮生长因子和白细胞介素-8）表达的显著抑制一致。此外，NF-κ B信号传导的阻断还显著抑制体外胶质母细胞瘤细胞的血管生成潜力和小鼠异种移植模型中脑肿瘤的血管生成。总的来说，这些结果表明，NF-κ B活化在胶质母细胞瘤的生长和进展中起着关键作用，并且是治疗人类胶质母细胞瘤的潜在靶点。
Angiogenesis is a key pathologic feature of glioblastoma, which is the most common and most lethal primary brain tumor in adults. The degree of angiogenesis has been shown to be inversely related to patient survival. However, the molecular changes leading to angiogenesis in glioblastoma remain poorly understood. In the present study, we found a direct correlation between nuclear factor (NF)-kappaB activation and angiogenesis in glioblastomas. Blockade of NF-kappaB signaling significantly inhibited glioblastoma growth and angiogenesis in nude mice. These effects were consistent with significant inhibition of the expression of multiple angiogenic molecules, including vascular endothelial growth factor, and interleukin-8, in vitro and in vivo. Furthermore, blockade of NF-kappaB signaling also significantly inhibited the angiogenic potential of glioblastoma cells in vitro and angiogenesis of brain tumors in mouse xenograft models. Collectively, these results suggest that NF-kappaB activation plays a critical role in the growth and progression of glioblastoma and is a potential target for therapy for human glioblastoma.
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影响因子：
11.2
作者：
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影响因子：
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作者：
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