In utero ventilation with oxygen augments left ventricular stroke volume in lambs.
In utero ventilation with oxygen augments left ventricular stroke volume in lambs.
复制标题
子宫内氧气通气可增加羔羊的左心室每搏输出量。
DOI：
10.1113/jphysiol.1987.sp016417
复制
发表时间：
1987
期刊：
影响因子：
--
通讯作者：
K. Thornburg
中科院分区：
文献类型：
--
作者：
M. Morton;C. Pinson;K. Thornburg
1.为探讨出生时每搏量增加的机制，对8只胎羊在宫内肺通气过程中的左心功能进行了研究。在手术中，胎儿准备了气管导管、主动脉电磁流量传感器以及颈动脉、颈静脉、心包和左房导管。2.在8.3+/-1.5(平均数+/-S.D.)之后术后天数和孕龄137+/-3d，分别在宫内进行肺通气前和期间进行血流动力学测定。3.通气组氧分压由7.3mldl-1升至14.7mldl-1(P<0.001)，右房压由3.0mldl-1升至4.5ml.6mgHg(P<0.001)，左房压由2.5mldl-1升至10.2+-3.7mmHgP<0.001。左心室每搏量1.1+/-0.4~1.9+/-1.2ml kg-1(P<0.05)，心率160+/-21~183+/-11次/min-1(P<0.05)。4.吸氧时，每搏输出量与左房压力的关系曲线上移。5.吸氧使左心室每搏量快速、可逆地增加，这与出生时的每搏量增加大致相同。
1. In order to determine mechanisms for increased stroke volume at birth, left ventricular function was investigated in eight fetal lambs during in utero pulmonary ventilation. At surgery fetuses were prepared with a tracheal tube, aortic electromagnetic flow sensor, and carotid, jugular, pericardial and left atrial catheters. 2. After 8.3 +/‐ 1.5 (mean +/‐ S.D.) post‐surgery days and at 137 +/‐ 3 days gestation, haemodynamic values were obtained before and during pulmonary ventilation in utero. 3. During ventilation, O2 content increased from 7.3 +/‐ 2.1 to 14.7 +/‐ 2.7 ml dl‐1 (P less than 0.001), right atrial pressure from 3.0 +/‐ 1.3 to 4.5 +/‐ 1.6 mmHg (P less than 0.05), left atrial pressure from 2.5 +/‐ 1.2 to 10.2 +/‐ 3.7 mmHg (P less than 0.001), left ventricular stroke volume from 1.1 +/‐ 0.4 to 1.9 +/‐ 1.2 ml kg‐1 (P less than 0.05), and heart rate from 160 +/‐ 21 to 183 +/‐ 11 beats min‐1 (P less than 0.05). 4. During O2 ventilation, left ventricular function curves relating stroke volume to left atrial pressure were shifted upward. 5. O2 ventilation produced rapid, reversible increases in left ventricular stroke volume which approximate increases in stroke volume at birth.
胎儿和产后绵羊心肌收缩力的发育变化：体外和体内。
DOI：
10.1152/ajpheart.1984.247.3.h371
发表时间：
1984
期刊：
The American journal of physiology
影响因子：
--
作者：
Anderson,PA;Glick,KL;Manring,A;CrenshawJr,C
通讯作者：
CrenshawJr,C
影响因子：
9.8
作者：
Anderson,PA;Manring,A;Glick,KL;CrenshawJr,CC
通讯作者：
CrenshawJr,CC
子宫内未麻醉胎羔通过正压通气改变动脉气体成分。
DOI：
10.1159/000242131
发表时间：
1985
期刊：
Biology of the neonate
影响因子：
--
作者：
Willis,DM;Anderson,DF;Thornburg,KL;Faber,JJ
通讯作者：
Faber,JJ