Neuronal survival strategies in the face of RNA viral infection.
Neuronal survival strategies in the face of RNA viral infection.
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面对 RNA 病毒感染的神经元生存策略。
DOI：
10.1086/344265
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发表时间：
2002
期刊：
影响因子：
--
通讯作者：
Rall,GlennF
中科院分区：
文献类型：
--
作者：
Patterson,CatherineE;Daley,JohnK;Rall,GlennF
Neurons of the mammalian central nervous system (CNS) are an essential and largely nonrenewable cell population. Thus, viral infections that result in neuronal depletion, either by viral lysis or by induction of the cytolytic immune response, would likely lead to profound neurologic impairment. However, many viral infections that result in tissue destruction elsewhere in the host produce few overt symptoms in the CNS, despite readily detectable virus expression. This observation has lead to the speculation that neurons possess strategies to limit the replication and spread of otherwise cytopathic viruses. These strategies either favor the clearance of virus in the absence of appreciable neuronal loss or promote the establishment of noncytolytic persistent infections. This review discusses some of these strategies, with an emphasis on how such survival techniques lessen the potential for CNS neuropathology
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