MyD88-dependent protective immunity elicited by adenovirus 5 expressing the surface antigen 1 from Toxoplasma gondii is mediated by CD8(+) T lymphocytes.
MyD88-dependent protective immunity elicited by adenovirus 5 expressing the surface antigen 1 from Toxoplasma gondii is mediated by CD8(+) T lymphocytes.
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DOI：
10.1016/j.vaccine.2011.04.044
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发表时间：
2011-06-15
期刊：
影响因子：
5.5
通讯作者：
Gazzinelli, Ricardo T.
中科院分区：
文献类型：
--
作者：
Mendes, Erica A.;Caetano, Braulia C.;Penido, Marcus L. O.;Bruna-Romero, Oscar;Gazzinelli, Ricardo T.
Toxoplasma gondii is an intracellular parasite widely spread around the world. The Surface Antigens (SAG) 1, 2 and 3 are the main proteins expressed on the surface of T. gondii tachyzoites. Replication-defective adenovirus serotype 5 (rAd5) is one of the most potent recombinant viral vectors for eliciting T cell-mediated immunity in mice and humans. Here we show that vaccination with rAd5 expressing SAG1 (AdSAG1), but neither SAG2 nor SAG3, induces protective immunity in the highly susceptible C57BL/6 mice challenged with T. gondii. Furthermore, we evaluated different immunological components involved on viral induced protective immunity. We observed that host protection elicited by AdSAG1 is highly dependent on IL-12, IFN-γ and CD8+ T lymphocytes. Importantly, the induction of protective immunity (T cell-derived IFN-γ) was also dependent on Myeloid Differentiation Factor 88 (MyD88), and thus, likely to involve Toll-Like receptors. We conclude that protective parasite specific-CD8+ T cells are elicited by a mechanism that involves MyD88-dependent induction of IL-12.
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影响因子：
5.4
作者：
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通讯作者：
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影响因子：
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作者：
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DOI：
10.1073/pnas.87.16.6191
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通讯作者：
PRINCE, GA
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6.4
作者：
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通讯作者：
Kovacs, JA