Vacuole inheritance regulates cell size and branching frequency of Candida albicans hyphae.
Vacuole inheritance regulates cell size and branching frequency of Candida albicans hyphae.
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DOI：
10.1111/j.1365-2958.2008.06545.x
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发表时间：
2009-01
影响因子：
3.6
通讯作者：
Gow NA
中科院分区：
文献类型：
--
作者：
Veses V;Richards A;Gow NA
Hyphal growth of Candida albicans is characterized by asymmetric cell divisions in which the subapical mother cell inherits most of the vacuolar space and becomes cell cycle arrested in G1, while the apical daughter cell acquires most of the cell cytoplasm and progresses through G1 into the next mitotic cell cycle. Consequently, branch formation in hyphal compartments is delayed until sufficient cytoplasm is synthesized to execute the G1 ‘START’ function. To test the hypothesis that this mode of vacuole inheritance determines cell cycle progression and therefore the branching of hyphae, eight tetracycline-regulated conditional mutants were constructed that were affected at different stages of the vacuole inheritance pathway. Under repressing conditions, vac7, vac8 and fab1 mutants generated mycelial compartments with more symmetrically distributed vacuoles and increased branching frequencies. Repression of VAC1, VAM2 and VAM3 resulted in sparsely branched hyphae, with large vacuoles and enlarged hyphal compartments. Therefore, during hyphal growth of C. albicans the cell cycle, growth and branch formation can be uncoupled, resulting in the investment of cytoplasm to support hyphal extension at the expense of hyphal branching.
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影响因子：
2.6
作者：
GIETZ, RD;SCHIESTL, RH;WOODS, RA
通讯作者：
WOODS, RA
影响因子：
--
作者：
Bachewich, C;Whiteway, M
通讯作者：
Whiteway, M
DOI：
10.1083/jcb.143.1.65
发表时间：
1998-10-05
期刊：
The Journal of cell biology
影响因子：
--
作者：
Gary JD;Wurmser AE;Bonangelino CJ;Weisman LS;Emr SD
通讯作者：
Emr SD
影响因子：
4.3
作者：
Barberis M;Klipp E;Vanoni M;Alberghina L
通讯作者：
Alberghina L
影响因子：
7.8
作者：
CONRADT, B;HAAS, A;WICKNER, W
通讯作者：
WICKNER, W