Traffic, susceptibility, and childhood asthma.
Traffic, susceptibility, and childhood asthma.
复制标题
DOI：
10.1289/ehp.8594
复制
发表时间：
2006-05
影响因子：
10.4
通讯作者：
Peters J
中科院分区：
文献类型：
--
作者：
McConnell R;Berhane K;Yao L;Jerrett M;Lurmann F;Gilliland F;Künzli N;Gauderman J;Avol E;Thomas D;Peters J
交通和儿童哮喘的研究结果不一致，但对易感亚群的系统评估很少。在这项研究中，我们调查了南加州学龄儿童（5-7岁）的当地交通相关暴露与哮喘和喘息的关系。通过问卷调查评估医生诊断的哮喘史及哮喘和喘息的流行情况。父母哮喘史和儿童过敏症状史、性别和早期生活暴露（自2岁起居住在同一家庭）作为易感因素进行了检查。住宅暴露程度通过靠近主要道路和模拟当地交通相关污染物暴露程度来评估。居住在主干道75米以内与终生哮喘风险增加相关[优势比(OR) = 1.29；95%可信区间（CI）， 1.01-1.86]，常见哮喘（OR = 1.50; 95% CI, 1.16-1.95）和喘息（OR = 1.40; 95% CI, 1.09-1.78）。无父母哮喘史的长期居民终生哮喘（OR = 1.85; 95% CI, 1.11-3.09）、哮喘流行（OR = 2.46; 95% CI, 0.48-4.09）和近期喘息（OR = 2.74; 95% CI, 1.71-4.39）的易感性增加。在离主干道150-200米的地方，哮喘的高风险降低到背景水平。在父母有哮喘史的儿童中，以及在2岁后迁入该住所的儿童中，暴露没有增加风险。住所靠近道路对女孩的影响也更大。在交通模拟暴露中也观察到类似的影响模式。这些结果表明，居住在主要道路附近与哮喘有关。对父母没有哮喘史的孩子影响更大的原因值得进一步调查。
Results from studies of traffic and childhood asthma have been inconsistent, but there has been little systematic evaluation of susceptible subgroups. In this study, we examined the relationship of local traffic-related exposure and asthma and wheeze in southern California school children (5–7 years of age). Lifetime history of doctor-diagnosed asthma and prevalent asthma and wheeze were evaluated by questionnaire. Parental history of asthma and child’s history of allergic symptoms, sex, and early-life exposure (residence at the same home since 2 years of age) were examined as susceptibility factors. Residential exposure was assessed by proximity to a major road and by modeling exposure to local traffic-related pollutants. Residence within 75 m of a major road was associated with an increased risk of lifetime asthma [odds ratio (OR) = 1.29; 95% confidence interval (CI), 1.01–1.86], prevalent asthma (OR = 1.50; 95% CI, 1.16–1.95), and wheeze (OR = 1.40; 95% CI, 1.09–1.78). Susceptibility increased in long-term residents with no parental history of asthma for lifetime asthma (OR = 1.85; 95% CI, 1.11–3.09), prevalent asthma (OR = 2.46; 95% CI, 0.48–4.09), and recent wheeze (OR = 2.74; 95% CI, 1.71–4.39). The higher risk of asthma near a major road decreased to background rates at 150–200 m from the road. In children with a parental history of asthma and in children moving to the residence after 2 years of age, there was no increased risk associated with exposure. Effect of residential proximity to roadways was also larger in girls. A similar pattern of effects was observed with traffic-modeled exposure. These results indicate that residence near a major road is associated with asthma. The reason for larger effects in those with no parental history of asthma merits further investigation.
登录
查看更多内容
影响因子：
24.3
作者：
Gautrin, D;Newman-Taylor, AJ;Malo, JL
通讯作者：
Malo, JL
DOI：
10.1164/ajrccm.163.2.2006009
发表时间：
2001-02-01
影响因子：
24.7
作者：
Gilliland, FD;Li, YF;Peters, JM
通讯作者：
Peters, JM
DOI：
10.1164/rccm.2112064
发表时间：
2002-08-15
影响因子：
24.7
作者：
Gilliland, FD;Li, YF;Peters, JM
通讯作者：
Peters, JM
影响因子：
9.8
作者：
Briggs, DJ;de Hoogh, C;Smallbone, K
通讯作者：
Smallbone, K
影响因子：
10.4
作者：
Jaakkola, JJK;Nafstad, P;Magnus, P
通讯作者：
Magnus, P