Infection of cultured human fetal pancreatic islet cells by rubella virus.
Infection of cultured human fetal pancreatic islet cells by rubella virus.
复制标题
风疹病毒对培养的人胎儿胰岛细胞的感染。
DOI：
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复制
发表时间：
1989
影响因子：
3.5
通讯作者：
M. Wainberg
中科院分区：
文献类型：
--
作者：
K. Numazaki;H. Goldman;I. Wong;M. Wainberg
A high incidence of insulin-dependent diabetes mellitus (IDDM) has been reported in children and young adults previously afflicted with congenital rubella syndrome (CRS). The authors have studied the effect of rubella virus infection on human pancreatic islet cells in tissue culture. These experiments were performed with the use of both monolayers and free-floating human fetal islets of Langerhans tissue. Levels of production of immunoreactive insulin by islet cells that had been infected by rubella virus were lower than those observed in control cultures, under conditions of high glucose concentration (11.1 mmol/L) in the medium. The presence of rubella viral antigens in human pancreatic beta and non-beta cells was demonstrated by double-label immunofluorescence. These results suggest that rubella virus can infect human pancreatic islet cells and that such infection may lead to significant reductions in levels of secreted insulin.
影响因子：
56.9
作者：
M. B. Oldstone;P. J. Southern;M. Rodríquez;P. W. Lampert
通讯作者：
M. B. Oldstone;P. J. Southern;M. Rodríquez;P. W. Lampert
先天性风疹综合征患者的糖尿病和自身免疫。
DOI：
10.1093/clinids/7.supplement_1.s170
发表时间：
1985
期刊：
Reviews of infectious diseases
影响因子：
--
作者：
Ginsberg-Fellner,F;Witt,ME;Fedun,B;Taub,F;Dobersen,MJ;McEvoy,RC;Cooper,LZ;Notkins,AL;Rubinstein,P
通讯作者：
Rubinstein,P