High-resolution peripheral quantitative computed tomography for the assessment of bone strength and structure: a review by the Canadian Bone Strength Working Group.
High-resolution peripheral quantitative computed tomography for the assessment of bone strength and structure: a review by the Canadian Bone Strength Working Group.
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DOI：
10.1007/s11914-013-0140-9
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发表时间：
2013-06
影响因子：
4.3
通讯作者：
Boyd SK
中科院分区：
文献类型：
--
作者：
Cheung AM;Adachi JD;Hanley DA;Kendler DL;Davison KS;Josse R;Brown JP;Ste-Marie LG;Kremer R;Erlandson MC;Dian L;Burghardt AJ;Boyd SK
骨结构是骨强度的一个不可分割的决定因素。高分辨率外周定量计算机断层扫描（HR-pQCT）的可用性使得在体内测量三维骨微结构和体积骨矿物质密度成为可能，其准确性以前无法实现，并且辐射剂量相对较低。最近使用这种新型成像工具的研究增加了我们对骨微结构中年龄相关变化和性别差异以及不同药物治疗效果的理解。这种新型工具的一个优点是使用有限元分析建模来非侵入性地估计骨强度，并使用重建的三维图像来预测骨折。在本文中，我们描述了HR-pQCT的优势和局限性，并回顾了使用该工具的临床研究。
Bone structure is an integral determinant of bone strength. The availability of high resolution peripheral quantitative computed tomography (HR-pQCT) has made it possible to measure three-dimensional bone microarchitecture and volumetric bone mineral density in vivo, with accuracy previously unachievable and with relatively low-dose radiation. Recent studies using this novel imaging tool have increased our understanding of age-related changes and sex differences in bone microarchitecture, as well as the effect of different pharmacological therapies. One advantage of this novel tool is the use of finite element analysis modelling to non-invasively estimate bone strength and predict fractures using reconstructed three-dimensional images. In this paper, we describe the strengths and limitations of HR-pQCT and review the clinical studies using this tool.
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影响因子：
6.2
作者：
Burrows, Melonie;Liu, Danmei;McKay, Heather
通讯作者：
McKay, Heather
影响因子：
6.2
作者：
Boutroy, Stephanie;Van Rietbergen, Bert;Delmas, Pierre D.
通讯作者：
Delmas, Pierre D.
影响因子：
6.2
作者：
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Melton, LJ
影响因子：
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作者：
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通讯作者：
Khosla, Sundeep
影响因子：
5.8
作者：
Boutroy, S;Bouxsein, ML;Delmas, PD
通讯作者：
Delmas, PD