A High Triglyceride-Glucose Index Is Associated With Contrast-Induced Acute Kidney Injury in Chinese Patients With Type 2 Diabetes Mellitus.
A High Triglyceride-Glucose Index Is Associated With Contrast-Induced Acute Kidney Injury in Chinese Patients With Type 2 Diabetes Mellitus.
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高甘油三酸酯 - 葡萄糖指数与中国2型糖尿病患者的对比诱导的急性肾损伤有关。
DOI：
10.3389/fendo.2020.522883
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发表时间：
2020
影响因子：
5.2
通讯作者：
Tang C
中科院分区：
文献类型：
--
作者：
Qin Y;Tang H;Yan G;Wang D;Qiao Y;Luo E;Hou J;Tang C
Triglyceride-glucose (TyG) is an emerging vital indicator of insulin resistance and is associated with increased risk of T2DM and cardiovascular events. We aimed to explore the TyG index and contrast-induced acute kidney injury (CI-AKI) in patients with type 2 diabetes who underwent coronary angiology. This study enrolled 928 patients with suspected coronary artery disease who underwent coronary angiology or percutaneous coronary intervention in Zhongda hospital. Patient data were divided into quartiles according to the TyG index: group 1: TyG ≤ 8.62; group 2: 8.62<TyG ≤ 9.04; group 3: 9.04<TyG ≤ 9.45; and group 4: TyG>9.45. CI-AKI was diagnosed according to the KIDIGO criteria. Demographic data, hematological parameters, coronary angiology data, and medications were all recorded. We calculated the TyG index using the following formula: ln [fasting TG (mg/dL)×FPG (mg/dL)/2]. Patients who developed CI-AKI exhibited significantly higher TyG index levels compared to patients who did not develop CI-AKI. The incidence of CI-AKI sharply increased with increasing TyG. Univariate and multivariate analysis identified TyG as an independent risk factor for CI-AKI. The AUC of the ROC curve was as high as 0.728 when the value of TyG was 8.88. The corresponding sensitivity was as high as 94.9%. Adding the variable TyG to the model for predicting CI-AKI risk further increased the predictive value of the model from 80.4% to 82%. High TyG is closely associated with increased incidence of CI-AKI, demonstrating that TyG is an independent risk factor for CI-AKI. TyG has potentially predictive value for CI-AKI and may play a crucial role in risk stratification in clinical practice.
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DOI：
10.1186/cc11454
发表时间：
2013-02-04
期刊：
Critical care (London, England)
影响因子：
--
作者：
Kellum JA;Lameire N;KDIGO AKI Guideline Work Group
通讯作者：
KDIGO AKI Guideline Work Group
影响因子：
5.1
作者：
Junqueira Vasques, Ana Carolina;Novaes, Fernanda Satake;Geloneze, Bruno
通讯作者：
Geloneze, Bruno
影响因子：
4.8
作者：
Khan SH;Sobia F;Niazi NK;Manzoor SM;Fazal N;Ahmad F
通讯作者：
Ahmad F
为什么糖尿病是对比诱导肾病的危险因素？
影响因子：
--
作者：
Heyman SN;Rosenberger C;Rosen S;Khamaisi M
通讯作者：
Khamaisi M
影响因子：
5.1
作者：
Barbieri, Lucia;Verdoia, Monica;De Luca, Giuseppe
通讯作者：
De Luca, Giuseppe