Neurovascular Relationships in AGEs-Based Models of Proliferative Diabetic Retinopathy.
Neurovascular Relationships in AGEs-Based Models of Proliferative Diabetic Retinopathy.
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DOI：
10.3390/bioengineering11010063
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发表时间：
2024-01-08
影响因子：
4.6
通讯作者：
Vazquez, Maribel
中科院分区：
文献类型：
--
作者：
Pena, Juan S.;Ramanujam, Ranjini K.;Risman, Rebecca A.;Tutwiler, Valerie;Berthiaume, Francois;Vazquez, Maribel
关键词：
糖尿病视网膜病变影响全球1亿多人，预计在20年内将增加50%。血糖升高导致晚期糖基化终产物（AGEs）的形成，其导致神经血管系统的细胞和分子功能障碍。这些分子启动视网膜血管系统和内部血视网膜屏障（iBRB）的缓慢破坏，导致缺血和异常血管生成。该项目研究了AGEs在改变组成iBRB的健康细胞形态方面的影响，以及AGEs对体外血栓形成的影响。我们的研究结果表明，AGEs显着改变细胞面积，并通过组织因子水平的升高增加血栓的形成。同样，AGEs上调内皮细胞和神经胶质细胞上的细胞受体（EGFR）的表达，这是糖尿病细胞中炎症的标志性生物标志物。检查AGEs刺激对细胞功能的影响，这些细胞功能会降低iBRB的完整性，这将极大地有助于推进针对成人视力丧失的治疗。
Diabetic retinopathy affects more than 100 million people worldwide and is projected to increase by 50% within 20 years. Increased blood glucose leads to the formation of advanced glycation end products (AGEs), which cause cellular and molecular dysfunction across neurovascular systems. These molecules initiate the slow breakdown of the retinal vasculature and the inner blood retinal barrier (iBRB), resulting in ischemia and abnormal angiogenesis. This project examined the impact of AGEs in altering the morphology of healthy cells that comprise the iBRB, as well as the effects of AGEs on thrombi formation, in vitro. Our results illustrate that AGEs significantly alter cellular areas and increase the formation of blood clots via elevated levels of tissue factor. Likewise, AGEs upregulate the expression of cell receptors (RAGE) on both endothelial and glial cells, a hallmark biomarker of inflammation in diabetic cells. Examining the effects of AGEs stimulation on cellular functions that work to diminish iBRB integrity will greatly help to advance therapies that target vision loss in adults.
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影响因子：
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作者：
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