ROLE OF CYTOCHROME P450S IN THE GENERATION AND METABOLISM OF REACTIVE OXYGEN SPECIES.
ROLE OF CYTOCHROME P450S IN THE GENERATION AND METABOLISM OF REACTIVE OXYGEN SPECIES.
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DOI：
10.1016/j.cotox.2017.10.003
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发表时间：
2018-03
影响因子：
4.6
通讯作者：
Moorthy B
中科院分区：
文献类型：
--
作者：
Veith A;Moorthy B
细胞色素P450（CYP）酶是一组不同的血红素单加氧酶，通过其反应循环过程，有助于细胞活性氧（ROS）。酶在人体生理学中起着至关重要的作用，参与药物和异生物质代谢以及内源性分子的生物合成，并在整个人体中表达。然而，在酶催化循环过程中，ROS可以通过酶循环的解偶联产生。已知ROS修饰内源性分子，包括脂质、蛋白质和核酸，其可导致细胞损伤和死亡并促进疾病发展。ROS与多种疾病和病症有关，包括癌症和衰老，但ROS也在细胞的正常生理功能中发挥作用。在这里，我们讨论了具体的例子，其中ROS产生的CYP有助于或防止各种现象，如高氧肺损伤，氧化性肝毒性，形成的DNA加合物的脂质过氧化产物。我们还讨论了属于不同家族的ROS酶的机制作用，以及它们对细胞ROS产生的影响，与正常细胞功能以及疾病病理生理学有关。
The cytochrome P450 (CYP) enzymes are a diverse group of heme monooxygenases that, through the course of their reaction cycle, contribute to cellular reactive oxygen species (ROS). CYP enzymes play a crucial role in human physiology and are involved in drug and xenobiotic metabolism as well as biosynthesis of endogenous molecules and are expressed throughout the human body. However, during the course of the CYP catalytic cycle, ROS can be generated through uncoupling of the enzymatic cycle. ROS is known to modify endogenous molecules, included lipids, proteins, and nucleic acids, which can lead to cell damage and death and contribute to disease development. ROS has been implicated in a wide range of diseases and conditions, including cancer and ageing, but ROS also play a role in the normal physiological functions in the cell. Here, we discuss specific examples whereby ROS generated by CYPs contribute to or protect against various phenomena, such as hyperoxic lung injury, oxidative hepatic toxicity, formation of DNA adducts from lipid peroxidation products. We have also discussed the mechanistic roles of CYP enzymes belonging to various families, and their effect on cellular ROS production, in relation to normal cellular function as well as disease pathophysiology.
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DOI：
10.1016/j.bbrc.2016.05.125
发表时间：
2016-08-05
影响因子：
3.1
作者：
Dinu D;Chu C;Veith A;Lingappan K;Couroucli X;Jefcoate CR;Sheibani N;Moorthy B
通讯作者：
Moorthy B
DOI：
10.1016/bs.apha.2015.05.002
发表时间：
2015
期刊：
Advances in pharmacology (San Diego, Calif.)
影响因子：
--
作者：
Johnson AL;Edson KZ;Totah RA;Rettie AE
通讯作者：
Rettie AE
影响因子：
6.6
作者：
Jones DP;Sies H
通讯作者：
Sies H
影响因子：
3.3
作者：
HAZINSKI, TA;FRANCE, M;HANSEN, TN
通讯作者：
HANSEN, TN
影响因子：
4.1
作者：
Guengerich FP
通讯作者：
Guengerich FP