Behavioral context affects social signal representations within single primate prefrontal cortex neurons.
Behavioral context affects social signal representations within single primate prefrontal cortex neurons.
复制标题
行为背景影响单个灵长类前额叶皮层神经元内的社会信号表征。
DOI：
10.1016/j.neuron.2022.01.020
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发表时间：
2022-04-20
期刊：
影响因子：
16.2
通讯作者：
Miller, Cory Thomas
中科院分区：
文献类型：
--
作者：
Jovanovic, Vladimir;Fishbein, Adam Ryan;de la Mothe, Lisa;Lee, Kuo-Fen;Miller, Cory Thomas
我们测试了是否社会信号处理在更传统的，头部受限的情况下是代表假定的自然模拟-社会沟通-通过比较在一系列的行为背景下，从传统到自然的绒猴前额叶皮层（PFC）的单个神经元内的发声反应。虽然发声反应神经元在所有情况下都很明显，但跨背景的一致性明显有限。当受试者被头部束缚时，对这些社会信号的反应并不能预测自然交流过程中对相同发声的类似神经反应。这种模式在个体神经元和群体水平上都很明显，因为PFC活动可以可靠地解码为听到发声的行为背景。这些结果表明，灵长类PFC中社会信号的神经表征不是静态的，而是高度灵活的，可能反映了动态行为环境的细微差别如何影响这些信号的感知以及它们所传达的内容。Jovanovic及其同事报告说，在传统的头部受限模式下，灵长类前额叶皮层的社会信号处理并不能代表自然交流中的类似过程。这些发现表明，灵长类动物社会脑功能的某些方面只能在自然发生的环境中阐明。
We tested whether social signal processing in more traditional, head-restrained contexts is representative of the putative natural analog – social communication – by comparing responses to vocalizations within individual neurons in marmoset prefrontal cortex (PFC) across a series of behavioral contexts ranging from traditional to naturalistic. Although vocalization responsive neurons were evident in all contexts, cross-context consistency was notably limited. A response to these social signals when subjects were head-restrained was not predictive of a comparable neural response to the identical vocalizations during natural communication. This pattern was evident both within individual neurons and at a population level, as PFC activity could be reliably decoded for the behavioral context in which vocalizations were heard. These results suggests that neural representations of social signals in primate PFC are not static, but highly flexible and likely reflect how nuances of the dynamic behavioral contexts affect the perception of these signals and what they communicate. Jovanovic and colleagues report that social signal processing in primate prefrontal cortex during traditional, head-restrained paradigms is not representative of the analogous process in natural communication. These findings suggest that some facets of primate social brain function can only be elucidated in the contexts in which they occur naturally.
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影响因子：
13.9
作者：
Freiwald W;Duchaine B;Yovel G
通讯作者：
Yovel G
DOI：
10.1038/s41583-020-0350-y
发表时间：
2020-10
期刊：
Nature reviews. Neuroscience
影响因子：
--
作者：
Gothard KM
通讯作者：
Gothard KM
DOI：
10.1007/s00359-009-0456-1
发表时间：
2009-08
影响因子：
2.1
作者：
Miller, Cory T.;Beck, Kaylin;Meade, Brooke;Wang, Xiaoqin
通讯作者：
Wang, Xiaoqin
影响因子：
4.3
作者：
Chang SW;Winecoff AA;Platt ML
通讯作者：
Platt ML
影响因子：
5.3
作者：
McMahon, David B. T.;Russ, Brian E.;Leopold, David A.
通讯作者：
Leopold, David A.